A 6 bp polymorphism in the thymidylate synthase gene causes message instability and is associated with decreased intratumoral TS mRNA levels
PharmacogeneticsPublished 27 April 2004
Michael V Mandola, Jan Stoehlmacher, Wu Zhang, Susan Groshen, Mimi C. Yu, Syma Iqbal
Citations302
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TL;DR
The results suggest that the 6 bp/1494 polymorphism in the 3'UTR of TS is associated with decreased mRNA stability in vitro and lower intratumoral TS expression in vivo, and may be a useful screening tool in predicting TS mRNA expression.
Abstract
These results suggest that the -6 bp/1494 deletion polymorphism in the 3'UTR of TS is associated with decreased mRNA stability in vitro and lower intratumoral TS expression in vivo. Further, the 6 bp/1494 polymorphism varies greatly within different ethnic populations and is in linkage disequilibrium with the TS 5' tandem repeat enhancer polymorphism. Taken together, these data suggest that the 6 bp/1494 polymorphism may be a useful screening tool in predicting TS mRNA expression.
Keywords
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