Hypersomnia in the Prader Willi syndrome: clinical-electrophysiological features and underlying factors
Clinical NeurophysiologyPublished 1 May 2001
Raffaele Manni, Lucia Politini, Lino Nobili, Franco Ferrillo, C. Livieri, E. Veneselli
Citations122
SJR quartileQ1
SJR score1.33
SNIP1.38
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TL;DR
Sleep disordered breathing appears to have a limited role in the genesis of hypersomnia which not seems on the other hand attributable to the coexistence of narcolepsy phenotype.
Abstract
Excessive sleepiness is a frequent disturbance in PWs. Subgroups of PW patients show hypersomnolence and SOREMPs. Sleep disordered breathing appears to have a limited role in the genesis of hypersomnia which not seems on the other hand attributable to the coexistence of narcolepsy phenotype. Hypersomnia in PW syndrome is likely to mainly be attributable to a primary hypothalamic dysfunction. The potential interacting role of other factors such as subjects age, sex and genetic pattern is suggested and deserve further investigation.
Keywords
Biochemistry, Genetics and Molecular Biology
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