A Cellular MicroRNA Mediates Antiviral Defense in Human Cells
SciencePublished 21 April 2005
Charles‐Henri Lecellier, Patrice Dunoyer, Khalil Arar, Jacqueline Lehmann‐Che, Stéphanie Eyquem, Christophe Himber
Citations898
SJR quartileQ1
SJR score10.42
SNIP6.62
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TL;DR
It is shown that a cellular microRNA effectively restricts the accumulation of the retrovirus primate foamy virus type 1 (PFV-1) in human cells and has direct antiviral effects in addition to their regulatory functions.
Abstract
In eukaryotes, 21- to 24-nucleotide-long RNAs engage in sequence-specific interactions that inhibit gene expression by RNA silencing. This process has regulatory roles involving microRNAs and, in plants and insects, it also forms the basis of a defense mechanism directed by small interfering RNAs that derive from replicative or integrated viral genomes. We show that a cellular microRNA effectively restricts the accumulation of the retrovirus primate foamy virus type 1 (PFV-1) in human cells. PFV-1 also encodes a protein, Tas, that suppresses microRNA-directed functions in mammalian cells and displays cross-kingdom antisilencing activities. Therefore, through fortuitous recognition of foreign nucleic acids, cellular microRNAs have direct antiviral effects in addition to their regulatory functions.
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Agricultural and Biological SciencesBiochemistry, Genetics and Molecular Biology
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