Pharmacotherapy of Attention-Deficit Hyperactivity Disorder across the Life Cycle
Journal of the American Academy of Child & Adolescent PsychiatryPublished 1 April 1996
Thomas Spencer, JOSEPH BIEDERMAN, Timothy E. Wilens, Margaret Harding, Deborah A. O’Donnell, Susan Griffin
Citations838
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TL;DR
The available literature indicates the important role of psychopharmacological agents in the reduction of the core symptoms of ADHD and associated impairments.
Abstract
The available literature indicates the important role of psychopharmacological agents in the reduction of the core symptoms of ADHD and associated impairments. More research is needed on alternative pharmacological treatments and to further evaluate established therapeutics beyond school-age Caucasian boys. In addition, more research is needed on the efficacy of treatment for comorbid ADHD, use of combined medications, and the combination of medication and psychosocial treatment.
Keywords
MedicineNeuroscience
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135 Citations1991Michael G. Aman, ROSEMARY E. MARKS +3 more
The present data suggest that mental age and IQ may be important determinants of drug response; below a given level, there was a greatly reduced likelihood of responding positively.
Journal of the American Academy of Child & Adolescent PsychiatryThe Response of Aggressive and Nonaggressive ADHD Children to Two Doses of Methylphenidate
135 Citations1989Russell A. Barkley, Mary B. McMurray +2 more
It is indicated that aggressive and nonaggressive ADHD children share a common disorder of ADHD but aggressives have more impaired family situations than nonaggressives.
Journal of the American Academy of Child PsychiatryTricyclic Antidepressant and Methylphenidate Treatment of Attention Deficit Disorder in Children
129 Citations1983Barry D. Garfinkel, Paul H. Wender +2 more
The need to understand better the amelioration of various ADD symptoms by different medications is underscored, with methylphenidate having a greater efficacy than the other drugs.
Archives of General PsychiatryTreatment of Hyperactive Children With Monoamine Oxidase Inhibitors
128 Citations1985Alan Zametkin
Findings of equivalent efficacy of MAOIs in ADD are in contrast to previous studies with neurotransmitter system selective agents, which showed only weak effects, and suggest that multiple neurotransmitter alterations may be required for stimulant drug effects in ADD.
JAMATics Following Methylphenidate Administration
128 Citations1976Martha B. Denckla
Among children receiving methylphenidate hydrochloride, tics developed in 14, and in six children with pre-existing tics, the tics became worse and the clinical diagnosis was minimal brain dysfunction (MBD), and in one case, Gilles de la Tourette syndrome.
Journal of the American Academy of Child & Adolescent PsychiatryMethylphenidate in Aggressive-Hyperactive Boys: I. Effects on Peer Aggression in Public School Settings
126 Citations1990Kenneth D. Gadow, Edith E. Nolan +3 more
Results showed that methylphenidate suppressed nonphysical aggression in the classroom, and a moderate dose decreased physical aggression and verbal aggression on the playground, and the effect on the rate of appropriate social interaction was variable.
Journal of the American Academy of Child & Adolescent PsychiatryTreatment of ADHD with fluoxetine: A preliminary trial
124 Citations1991Les Barrickman, Russell Noyes +3 more
It is suggested that fluoxetine may prove to be an alternative treatment for some attention-deficit hyperactivity disorder patients.
NeurologyGilles de la Tourette's syndrome
122 Citations1985Gerald Erenberg, Robert P. Cruse +1 more
The medication histories in 200 children with Gilles de la Tourette's syndrome were reviewed to investigate how frequently CNS stimulants may unmask a latent syndrome or worsen existing tics.
Journal of the American Academy of Child & Adolescent PsychiatryChanges in Family Function and Relationships in Children Who Respond to Methylphenidate
122 Citations1987Russell Schachar, Eric Taylor +3 more
Effects of methylphenidate on family function and relationships were assessed in boys 6 to 10 years of age presenting with overactivity and/or defiance and among responders, there was increased maternal warmth, decreased maternal criticism, greater frequency of maternal contact, and fewer negative encounters with siblings.
Journal of Child and Adolescent PsychopharmacologyGuanfacine for Treatment of Attention-Deficit Hyperactivity Disorder in Boys
117 Citations1995Joseph P. Horrigan, L. Jarrett Barnhill
The guanfacine appeared to be effective in reducing the target symptoms, with minimal side effects, in boys with ADHD.
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