Repeated stress causes reversible impairments of spatial memory performance
Brain ResearchPublished 1 March 1994
Victoria N. Luine, Miriam Villegas, Carlos J. Martinez, Bruce S. McEwen
Citations757
SJR quartileQ2
SJR score0.85
SNIP0.72
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TL;DR
These effects on behavior parallel the reversible stress-induced atrophy of dendrites of hippocampal CA3 neurons that are also blocked by the drugs.
Abstract
Restraint stress, 6 h/day for 21 days, caused an impairment, during acquisition, of the performance of a spatial memory task, the eight-arm radial maze. The impairment was reversible, temporally limited and blocked by phenytoin, a blocker of excitatory amino acid action, or tianeptine, an antidepressant, which lowers extracellular serotonin. These effects on behavior parallel the reversible stress-induced atrophy of dendrites of hippocampal CA3 neurons that are also blocked by the drugs.
Keywords
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