Sensitivity of Dictyostelium discoideum to nucleic acid analogues
Experimental Cell ResearchPublished 1 February 1971
William F. Loomis
Citations241
SJR quartileQ2
SJR score1.01
SNIP0.70
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TL;DR
Growth of axenic cultures of Dictyostelium discoideum A3 was shown to be inhibited by 5-fluorouracil, 5- fluorodeoxyuridine and 5-bromodeoxyURidine.
Abstract
Growth of axenic cultures of Dictyostelium discoideum A3 was shown to be inhibited by 5-fluorouracil, 5-fluorodeoxyuridine and 5-bromodeoxyuridine. Drug-resistant mutants were isolated and described.
Keywords
Materials ScienceBiochemistry, Genetics and Molecular Biology
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In stationary phase cells that had entered the developmental program leading to fruiting body construction, the rRNA turned over rapidly so that by the end of development at least 75% of the ribosomes fabricated during exponential growth had disappeared and had been replaced by new ones synthesized during the morphogenetic sequence.
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Journal of BacteriologyTemperature-sensitive Mutants of <i>Dictyostelium discoideum</i>
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Three classes of temperature-sensitive mutants of the cellular slime mold Dictyostelium discoideum have been isolated and results indicate that severalTemperature-sensitive and morphological mutations are recessive and nonidentical.
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A comparative study of morphogenetically deficient mutants has revealed that strains incapable of proceeding beyond a particular developmental stage are likewise incapable of applying those controls over transferase activity which the wild type exerts during the subsequent development.
Biological BulletinON THE RELATION BETWEEN GROWTH AND MORPHOGENESIS IN THE SLIME MOLD DICTYOSTELIUM DISCOIDEUM
28 Citations1956Maurice Sussman
The growth kinetics of Dictyostelium discoideum have been determined on complete and restricted media and the bearing of these results upon the mechanisms of cellular differentiation during slime mold development is discussed.
