MnSOD polymorphism and breast cancer in a population-based case–control study
Cancer LettersPublished 7 August 2003
Kathleen M. Egan, Patricia A. Thompson, Linda Titus‐Ernstoff, Jason H. Moore, Christine B. Ambrosone
Citations74
SJR quartileQ1
SJR score2.76
SNIP1.54
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TL;DR
Results do not support any overall association of the Ala-9Val MnSOD polymorphism to the development of breast cancer.
Abstract
A polymorphism in the signal sequence (Ala-9Val) of the gene encoding the free radical-quenching manganese superoxide dismutase (MnSOD) has been reported to alter the risk for breast cancer. We evaluated this relationship in a population-based case-control study (476 breast cancer cases and 502 controls). Overall, relative risks were not significantly elevated in women with one (RR: 1.27; 95% CI: 0.91-1.77) or two (RR: 1.18; 95% CI: 0.81-1.73) Ala alleles compared to those homozygous for the wild-type Val genotype. Results do not support any overall association of the Ala-9Val MnSOD polymorphism to the development of breast cancer.
Keywords
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