Are physiological oxygen concentrations mutagenic?
NaturePublished 1 August 1978
Walter J. Bruyninckx, Howard S. Mason, Stephen A. Morse
Citations78
SJR quartileQ1
SJR score18.29
SNIP10.16
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TL;DR
It is found that oxygen tensions physiological to higher animals are mutagenic towards these organisms.
Abstract
HYPERBARIC oxygen is known to be mutagenic towards Escherichia coli1–3. But, can oxygen be mutagenic at tensions physiological to man? We have studied this question using oxygen-sensitive mutants of the histidine auxotroph strain TA100 of Salmonella typhimurium constructed by Ames and his coworkers as part of a test system for carcinogens4. We find that oxygen tensions physiological to higher animals are mutagenic towards these organisms.
Keywords
Biochemistry, Genetics and Molecular BiologyEnvironmental Science
Mutation Research/Environmental Mutagenesis and Related SubjectsMethods for detecting carcinogens and mutagens with the salmonella/mammalian-microsome mutagenicity test
7,414 Citations1975Bruce N. Ames, Joyce McCann +1 more
The methods described include the standard plate test, the use and storage of the bacterial tester strains, preparation and use of the liver homogenates, and the methods of inducing the rats for elevated microsomal enzyme activity.
Journal of Applied BacteriologyFifth Stenhouse‐Williams Memorial Lecture Oxygen and the Obligate Anaerobe
81 Citations1976J. G. Morris
Proceedings of the National Academy of SciencesMUTAGENIC EFFECTS OF HIGH OXYGEN TENSIONS ON ESCHERICHIA COLI
53 Citations1957Wallace O. Fenn, R. Gerschman +3 more
To determine whether high pressure of oxygen would cause mutations in Escherichia coli similar to the e caused by radiation and demonstrated by Demerec, a streptomycindependent strain was supplied and detailed descriptions of the method used were furnished.
Archives of Biochemistry and BiophysicsSuperoxide and hydrogen peroxide in oxygen damage
33 Citations1976Fred J. Yost, Irwin Fridovich
It is likely that both O 2 − and H 2 O 2 are important agents of oxygen toxicity, and in accord with this conclusion were the observations that augmented intracellular levels of these enzymes correlated with increased resistance towards oxygen damage, whereas increased respiratory capacity correlation with increased sensitivity towards hyperbaric oxygen.
Biochemical and Biophysical Research CommunicationsMutation of an auxotrophic strain of Escherichia coli by high pressure oxygen
31 Citations1968G. D. Gifford
The results support the hypothesis that high pressures of oxygen are mutagenic in E. coli by supporting the possibility that at the time of pressure increase relatively more mutant than normal cells were in the resistant state and that during the period of exposure these might divide, thus giving an increase in mutant frequency and even a increase in the total number of mutants.