Familial differences in schizophrenia with good and poor prognosis
Psychological MedicinePublished 1 August 1971
Michael McCabe, Richard C. Fowler, Remi J. Cadoret, George Winokur
Citations78
SJR quartileQ1
SJR score2.42
SNIP1.85
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
The families with poor prognosis contained significantly more schizophrenia, neurosis, and overall illness, but less affective disorder than the families with good prognosis.
Abstract
SYNOPSIS Probands with schizophrenia of good and poor prognosis were selected according to defined criteria. Families were investigated blindly. The families with poor prognosis contained significantly more schizophrenia, neurosis, and overall illness, but less affective disorder than the families with good prognosis.
Keywords
PsychologyMedicine
American Journal of PsychiatryEstablishment of Diagnostic Validity in Psychiatric Illness: Its Application to Schizophrenia
2,211 Citations1970Eli Robins, Samuel B. Guzé
It was shown by follow-up and family studies that poor prognosis cases can be validly separated clinically from good prediction cases, and the authors conclude that good prognosis "schizophrenia" is not mild schizophrenia, but a different illness.
The British Journal of PsychiatryPsychiatric Disorders in Foster Home Reared Children of Schizophrenic Mothers
774 Citations1966Leonard L. Heston
The place of genetic factors in the aetiology of schizophrenia remains disputed, but several surveys have demonstrated a significantly higher incidence of the disorder in relatives of schizophrenic persons as compared to the general population.
The British Journal of PsychiatryReliability of a Procedure for Measuring and Classifying “Present Psychiatric State”
373 Citations1967J. K. Wing, J. L. T. Birley +3 more
A structured "present state" interview has been developed and tested and introduces a degree of standardization and precision which suggests that more of the diagnostic process might be brought under control with obvious benefit to clinical practice and research.
Archives of General PsychiatryProspective Prediction Of Schizophrenic Remission
316 Citations1964George E. Vaillant
There is no well-documented method for predicting on admission the longterm clinical course of schizophrenics, but there are three studies that have been well-enough designed to merit clinical confidence.
American Journal of PsychiatryThe genetic theory of schizophrenia. An analysis of 691 schizophrenic twin index families. 1946 [classical article]
309 Citations1994Franz J. Kallmann
American Journal of PsychiatryTHE GENETIC THEORY OF SCHIZOPHRENIA
289 Citations1946Franz J. Kallmann
A study of the relative effects of hereditary and environmental factors in the development and outcome of schizophrenia was undertaken by means of the "Twin Family Method", involving 1,382 twins and 691 twin index families.
Archives of General PsychiatryCriminality and Psychiatric Disorders
284 Citations1969Samuel B. Guzé
The extent of criminal behavior and the role of psychiatry in understanding and modifying this extensive and costly criminal behavior is not clear and is a subject of controversy.
American Journal of PsychiatryFamily History Studies: V. The Genetics of Mania
211 Citations1969Theodore Reich, Paula J. Clayton +1 more
The Journal of Nervous and Mental DiseaseTHE PREDICTION OF RECOVERY IN SCHIZOPHRENIA
156 Citations1962George E. Vaillant
Comprehensive PsychiatryFamily history studies: III schizoaffective disorder, clinical and genetic factors including a one to two year follow-up
120 Citations1968Paula J. Clayton, Leonard Rodin +1 more
Archives of General PsychiatryFunctional Psychoses: Diagnostic and Prognostic Models.
68 Citations1967Edward A. Wolpert
The British Journal of PsychiatryFamily History Studies: VII. Manic Depressive Disease Versus Depressive Disease
46 Citations1970Remi J. Cadoret, George Winokur +1 more
To account for the marked preponderance of ill females associated with female probands, this work postulates the presence of two groups of unipolar illness: one in which males and females have equal morbid risks, and the other in which the illness is sex-limited to females.
Psychiatric QuarterlyThe incidence of psychoses and other mental abnormalities in the families of recovered and deteriorated schizophrenic patients
36 Citations1942Otto Kant
The distribution among the different degrees of familial relationship confirms the generally accepted dominance of manic-depressive disease and the more frequent appearance of schizophrenia in the collateral lines.
American Journal of PsychiatryPARENTAL DEVIANCE AND THE GENESIS OF SOCIOPATHIC PERSONALITY
35 Citations1962Patricia O’Neal, Lee N. Robins +2 more
Most patients who met the criteria for a diagnosis of sociopathic personality at any time during their adult lives still showed marked antisocial behavior up to time of follow-up, and for those in whom there was a marked diminution of symptoms, this most often occurred between the ages of 30-35.