Lithium slows rat circadian activity rhythms
Life SciencesPublished 1 April 1980
Daniel F. Kripke, V.Grant Wyborney
Citations131
SJR quartileQ1
SJR score1.31
SNIP1.07
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
Abstract
Lithium slowed and split the wheel-running circadian rhythms of blinded rats.
Keywords
Neuroscience
PubMedCircadian rhythm disorders in manic-depressives.
358 Citations1978Daniel F. Kripke, Daniel J. Mullaney +2 more
A circadian etiology is consistent with the genetics and age distribution of manic-depressive illness and affective disturbances could be evolutionary remnants of the photo-periodic seasonal responses in animals.
Zeitschrift für Naturforschung CA Slowing Down of Circadian Rhythms by Lithium Ions
100 Citations1973Wolfgang Engelmann
It is hypothesized that the therapeutic effect of lithium salts in endogenous depressions in human beings may result also from its acting on the human circadian system.
Acta Psychiatrica ScandinavicaDepression and daily temperature
76 Citations1976B. Pflug, Robert C. Erikson +1 more
Changes were found in the daily temperature rhythm which resulted in a temperature maximum earlier in the day during the depression, which can be explained as indicating a desynchronization phenomenon of the circadian rhythms.
PubMedAutorhythmometry in manic-depressives.
63 Citations1976Martha Atkinson, D F Kripke +1 more
Systematic acrophase changes over time supported the hypothesis that manic-depressives have circadian rhythms that free-run faster than one cycle per 24 hrs and appeared to slow these rhythms and help the environmental synchronizer force physiological functions to coordinate better with the usual 24-h environmental cycles.
Zeitschrift für Naturforschung CFurther Evidence for Period Lengthening Effect of Li<sup>+</sup> on Circadian Rhythms
58 Citations1978Karlfriedrich Hofmann, M. Günderoth-Palmowski +2 more
The period length of the activity rhythm of the cockroach Leucophaea maderae is increased by LiCl solution of 100 mol m-3 offered as drinking water by about 1%.