LONG-TERM EFFICACY OF SILDENAFIL AND TACHYPHYLAXIS EFFECT
The Journal of UrologyPublished 1 September 2001
Rizk El-Galley, Harry Rutland, Riyadh F. Talic, Thomas E. Keane, HARRY CLARK
Citations112
SJR quartileQ1
SJR score2.21
SNIP2.70
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
Abstract
Our data suggest that there is a possible tachyphylaxis effect with sildenafil. Of the patients who were followed for 2 years 20% had to increase the sildenafil dose to have the same effect and 17% discontinued use due to loss of efficacy.
Keywords
PsychologyMedicineBiochemistry, Genetics and Molecular Biology
Campbell's urology
3,473 Citations1986M Patrick C. Walsh
Pediatric Urology Normal and Anomalous Development of the Urogenital System Renal Function in the Fetus, Neonate, and Child Perinatal Urology Evaluation of the Pediatric Urologic Patient Renal Disease in Childhood Urinary Tract.
New England Journal of MedicineOral Sildenafil in the Treatment of Erectile Dysfunction
2,133 Citations1998Irwin Goldstein, Tom F. Lue +4 more
JAMANIH Consensus Conference. Impotence. NIH Consensus Development Panel on Impotence
842 Citations1993
JAMASildenafil for Treatment of Erectile Dysfunction in Men With Diabetes
619 Citations1999Marc Rendell, Jacob Rajfer +3 more
Oral sildenafil is an effective and well-tolerated treatment for erectile dysfunction in men with diabetes.
British Journal of UrologySildenafil, a novel effective oral therapy for male erectile dysfunction
576 Citations1996Mitra Boolell, S Gepi-Attee +2 more
Results show that sildenafil is a well tolerated and effective oral therapy for male erectile dysfunction with no established organic cause and may represent a new class of peripherally acting drug for the treatment of this condition.
The Journal of UrologyOral sildenafil in the treatment of erectile dysfunction
498 Citations2002Irwin Goldstein, Tom F. Lue +5 more
The Journal of UrologyClinical Guidelines Panel on Erectile Dysfunction: Summary Report on the Treatment of Organic Erectile Dysfunction
216 Citations1996Drogo K. Montague, James H. Barada +6 more
Yohimbine does not appear to be effective for organic erectile dysfunction and, thus, it should not be recommended as treatment for the standard patient, and 3 treatment alternatives are recommended: vacuum constriction devices, vasoactive drug injection therapy and penile prosthesis implantation.
UrologyTreatment of erectile dysfunction after radical prostatectomy with sildenafil citrate (Viagra)
173 Citations1998Craig D. Zippe, Anurag W. Kedia +3 more
NeurologyEfficacy and safety of oral sildenafil (Viagra) in men with erectile dysfunction caused by spinal cord injury
153 Citations1998F. Derry, W W Dinsmore +5 more
Oral sildenafil, taken as required (not more than once daily), significantly improves the quality of erections and satisfaction with sex life in men with erectile dysfunction caused by a spinal cord injury between T6 and L5.
Journal of AndrologyEfficacy and Safety of Sildenafil Citrate for Treatment of Erectile Dysfunction in a Population With Associated Organic Risk Factors
143 Citations2001André T. Guay, Jesús B. Perez +2 more
Clinicians should be particularly careful to evaluate patients presenting with ED because the condition can be accompanied by a wide spectrum of risk factors requiring monitoring and treatment, and with adequate treatment and control of these risk factors, the use of sildenafil in a representative population of men with ED in a multispecialty clinic can achieve a higher efficacy rate than previous studies have indicated.
Clinical TherapeuticsSafety and efficacy of sildenafil citrate in the treatment of male erectile dysfunction
118 Citations1998Marvin M. Goldenberg
Sildenafil was associated with statistically significant improvement in erectile function compared with placebo and is contraindicated in men who are taking organic nitrates, because of the potential for a precipitous decrease in blood pressure.
UrologyTreatment of erectile dysfunction with sildenafil
107 Citations1999Leonard S. Marks, Catherine Duda +3 more
In clinical practice, sildenafil is an effective treatment of ED, according to partner-validated questionnaire responses; and the results of treatment are predictable with an ED severity classification system.
The American Journal of CardiologyNew insights into mechanisms underlying nitrate tolerance
92 Citations1996Thomas Münzel, Sabine Kurz +2 more
Increased circulating levels of angiotensin II, which are encountered during in vivo nitroglycerin treatment, initiate cellular events that ultimately attenuate the nitrogoglyin vasodilator effects during prolonged treatment periods, which strongly suggest that the hemodynamic and anti-ischemic efficacy of organic nitrates is rapidly blunted due to the development of nitrate tolerance.
The Journal of UrologyALTERATIONS IN ENDOTHELIN B RECEPTOR SITES IN CAVERNOSAL TISSUE OF DIABETIC RABBITS: POTENTIAL RELEVANCE TO THE PATHOGENESIS OF ERECTILE DYSFUNCTION
83 Citations1997Mark E. Sullivan, Michael R. Dashwood +4 more
The autoradiographic and immunohistochemical findings in this study suggest that ET-1 may have a role in the pathophysiology of diabetic ED.
British Journal of UrologyEvaluation of fine‐needle aspiration cytology for renal masses
82 Citations2000R.D. Brierly, Philip Thomas +4 more
To evaluate the accuracy and use of fine‐needle aspiration (FNA) cytology for the diagnosis of renal masses because with the improved quality and increasing use of ultrasonography and computed tomography, asymptomatic renal masses, par‐ticularly small (< 5 cm) tumours, are being discovered more frequently.
Heart Failure ReviewsCrosstalk Between Endothelin and Nitric Oxide in the Control of Vascular Tone
79 Citations2001Michel Lavallée, Masayuki Takamura +2 more
Experimental strategies designed to assess endothelial NO-dependent activity by the blockade of NO formation may be mitigated by magnified ET-dependent influences.
European Journal of PharmacologyThe effect of sildenafil on corpus cavernosal smooth muscle relaxation and cyclic GMP formation in the diabetic rabbit
60 Citations2001Cecil S. Thompson, Faiz Mumtaz +6 more
The use of sildenafil as an effective, orally administered, treatment for diabetic erectile dysfunction is supported and the impairment of NO-mediated relaxation of the corpus cavernosum is suggested to reflect, at least in part, a defect in guanylyl cyclase activity.
UrologyMuse therapy: preliminary clinical observations
59 Citations1997Philip Werthman, Jacob Rajfer
It is suggested that intracavernosal injections appear to be more effective than MUSE in achieving a rigid erection in men with erectile dysfunction.
Journal of the American College of CardiologyEffects of a nitrate-free interval on tolerance, vasoconstrictor sensitivity and vascular superoxide production
50 Citations2000Thomas Münzel, Hanke Mollnau +7 more
Enhanced vasoconstrictor sensitivity may explain, at least in part, the rebound phenomena observed in patients during a 12-h NTG patch-off period.
Diabetic MedicineTreatment of Male Erectile Dysfunction Using the Active Vacuum Assist Device
47 Citations1994H. J. Bodansky
The efficacy and acceptability of a new battery‐powered vacuum assist device, the ‘Active’ was assessed over 6 months in 19 diabetic men, median age 59 (38–66) years, of whom 9 had ECG evidence of autonomic neuropathy.
Endocrine PracticeCharacterization Of Patients In A Medical Endocrine-Based Center For Male Sexual Dysfunction
34 Citations1999André T. Guay, Ernesto Lara Velásquez +1 more
In a sexual dysfunction clinic managed by an endocrinologist, referral bias may direct more patients with hypogonadism and fewer patients who have had transurethral retropubic prostatectomy or a radical prostateCTomy.
Receptors and Responses
2 Citations1993Howard R. Petty
This chapter will learn how receptors are studied, the major classes of membrane receptors, and how a ligand’s signal is transduced into the cytoplasm to affect a physiological response.
