Adverse effects profile of the herbal antidepressant St. John's wort ( Hypericum perforatum L.)

The data suggest that hypericum is well tolerated, with an incidence of adverse reactions similar to that of placebo, as most of the current data originate from short-term investigations, more long-term studies are desirable.

Abstract

Hypericum has an encouraging safety profile. However, as most of the current data originate from short-term investigations, more long-term studies are desirable.