A comprehensive analysis of phase I and phase II metabolism gene polymorphisms and risk of colorectal cancer
Pharmacogenetics and GenomicsPublished 1 August 2005
Stefano Landi, Federica Gemignani, Vı́ctor Moreno, Lydie Gioia‐Patricola, Amélie Chabrier, Elisabet Guinó
Citations148
SJR quartileQ2
SJR score0.55
SNIP0.56
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TL;DR
An association study aimed to investigate the role of single nucleotide polymorphisms within genes of phase I and phase II of the xenobiotic metabolism suggests a role for CYP1B1 and CYP 1A1 as new candidate genes in the etiology of CRC and confirms the carcinogenic role of aromatic amines metabolism for colorectum.
Abstract
The present data suggest a role for CYP1B1 and CYP1A1 as new candidate genes in the etiology of CRC and confirm the carcinogenic role of aromatic amines metabolism for colorectum.
Keywords
MedicineBiochemistry, Genetics and Molecular BiologyPharmacology, Toxicology and Pharmaceutics
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