Cellular generators of the cortical auditory evoked potential initial component
Electroencephalography and Clinical Neurophysiology/Evoked Potentials SectionPublished 1 March 1992
Mitchell Steinschneider, Craig E. Tenke, Charles E. Schroeder, Daniel C. Javitt, Gregory V. Simpson, Joseph C. Arezzo
Citations140
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TL;DR
Findings indicate that thalamocortical afferents are a generator of N8 and support a role for lamina 4 stellate cells in the initial AEP of awake monkeys, and relationships to the human AEP are discussed.
Abstract
Cellular generators of the initial cortical auditory evoked potential (AEP) component were determined by analyzing laminar profiles of click-evoked AEPs, current source density, and multiple unit activity (MUA) in primary auditory cortex of awake monkeys. The initial AEP component is a surface-negative wave, N8, that peaks at 8-9 msec and inverts in polarity below lamina 4. N8 is generated by a lamina 4 current sink and a deeper current source. Simultaneous MUA is present from lower lamina 3 to the subjacent white matter. Findings indicate that thalamocortical afferents are a generator of N8 and support a role for lamina 4 stellate cells. Relationships to the human AEP are discussed.
Keywords
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