Cloning and functional analysis of rat cyclin D2 promoter: multiple prolactin‐responsive elements
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TL;DR
The results show that the expression of rat cyclin D2 gene is not dependent on the TATA‐box but is stimulated by multiple transcription factors induced by prolactin at an immediate‐early stage of the cell cycle.
Abstract
Structure and function of the promoter region of rat cyclin D2 gene were investigated by cloning, sequence analysis and DNA mobility shift assay using nuclear extracts of prolactin-stimulated Nb2 cells. The results show that the expression of rat cyclin D2 gene is not dependent on the TATA-box but is stimulated by multiple transcription factors induced by prolactin at an immediate-early stage of the cell cycle.