Insights into host responses against pathogens from transcriptional profiling
Nature Reviews MicrobiologyPublished 1 April 2005Open access
Richard G. Jenner, Richard A. Young
Citations589
SJR quartileQ1
SJR score13.86
SNIP10.67
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TL;DR
This review collated and compared published transcriptional-profiling data from 32 studies that involved 77 different host–pathogen interactions, and has defined a common host-transcriptional-response.
Abstract
DNA microarrays have allowed us to monitor the effects of pathogens on host-cell gene expression programmes in great depth and on a broad scale. The comparison of results that have been generated by these studies is complex, and such a comparison has not previously been attempted in a systematic manner. In this review, we have collated and compared published transcriptional-profiling data from 32 studies that involved 77 different host-pathogen interactions, and have defined a common host-transcriptional-response. We outline gene expression patterns in the context of Toll-like receptor and pathogen-mediated signalling pathways, and summarize the contributions that transcriptional-profiling studies have made to our understanding of the infectious disease process.
Keywords
Biochemistry, Genetics and Molecular Biology
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Innate, cell-mediated, and humoral immune responses were markedly upregulated in animals that significantly reduced their viral loads and retained more intestinal CD4+ T cells, indicating a complex dysregulation of growth and proliferation within the intestinal mucosa.
Journal of VirologyLatent Herpes Simplex Virus Infection of Sensory Neurons Alters Neuronal Gene Expression
65 Citations2003Martha F. Kramer, W. James Cook +5 more
It is demonstrated that latent HSV infection can alter neuronal gene expression and might provide a new mechanism for how persistent viral infection can cause chronic disease.
Proceedings of the National Academy of SciencesProtective immunity against <i>Helicobacter</i> is characterized by a unique transcriptional signature
62 Citations2003Anne Mueller, Jani O’Rourke +5 more
A mechanism of protection that involves the effector responses of either or both lymphocyte subclasses as well as the previously unappreciated paracrine functions of adipose tissue surrounding the resident lymphocytes is proposed.
The Journal of Infectious DiseasesDifferential Expression of Proinflammatory Cytokine Genes In Vivo in Response to Pathogenic and Nonpathogenic Pneumovirus Infections
60 Citations2002Joseph B. Domachowske, Cynthia A. Bonville +2 more
The results suggest that pneumovirus replication alone is insufficient to promote antiviral inflammation and that evaluation of the more divergent strain-specific pneumov virus proteins may provide some intriguing leads toward the molecular basis of this differential response.
Journal of Medical PrimatologyMicroarray analysis of cytokine and chemokine genes in the brains of macaques with SHIV‐encephalitis
51 Citations2003Yongjun Sui, Raghava Potula +11 more
A comprehensive spectrum of gene expression is provided that underscores the two major clinical manifestations of this unique syndrome: enhanced virus replication in brain macrophages and dystrophic changes in neurons.
Cellular MicrobiologyGene expression patterns of epithelial cells modulated by pathogenicity factors of<i>Yersinia enterocolitica</i>
51 Citations2004Erwin Bohn, Susanne Müller +9 more
Both Inv and YopP appear to modulate gene expression in order to subvert epithelial cell functions involved in innate immunity.
The Journal of ImmunologyA Role for Toll-Like Receptor 4 in Dendritic Cell Activation and Cytolytic CD8+ T Cell Differentiation in Response to a Recombinant Heat Shock Fusion Protein
43 Citations2004Deborah Palliser, Qian Huang +5 more
Results indicate that this Hsfp can activate DC independently of LPS but still requires Tlr4 for an optimal CD8 T cell response.
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