Inflammation and Mortality in HIV-Infected Adults: Analysis of the FRAM Study Cohort
JAIDS Journal of Acquired Immune Deficiency SyndromesPublished 25 June 2010Open access
Phyllis C. Tien, Andy I. Choi, Andrew Zolopa, Constance A. Benson, Russell P. Tracy, Rebecca Scherzer
Citations279
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TL;DR
Fibrinogen and CRP are strong and independent predictors of mortality in HIV-infected adults and suggest that even in those with relatively preserved CD4 counts >500 cells per microliter, inflammation remains an important risk factor for mortality.
Abstract
Fibrinogen and CRP are strong and independent predictors of mortality in HIV-infected adults. Our findings suggest that even in those with relatively preserved CD4 counts >500 cells per microliter, inflammation remains an important risk factor for mortality. Further investigation should determine whether interventions to reduce inflammation might decrease mortality risk in HIV-infected individuals.
Keywords
Immunology and MicrobiologyMedicine
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