Treatment of pediatric hodgkin disease tailored to stage, mediastinal mass, and age an italian (aieop) multicenter study on 215 patients
CancerPublished 15 September 1993Open access
Vico Vecchi, Stefano Pileri, Roberta Burnelli, Nadia Bontempi, A Comelli, Anna Maria Testi
Citations68
SJR quartileQ1
SJR score2.95
SNIP1.90
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TL;DR
A multicenter study tailored according to stage, bulky mediastinal mass, and age to optimize treatment results in pediatric Hodgkin disease while minimizing major side effects is presented.
Abstract
The encouraging results in early-stage disease indicate the validity of using less toxic treatment in this subgroup to maximize quality of life. Patients with bulky mediastinal disease tended to fare worse than those with M/T < 0.33 or without mediastinal involvement (FFP at 7 years: 69.4% versus 93.3%) and showed early local recurrence. In advanced stages, the eight-drug combination regimen (MOPP/ABVD) plus low-dose radiation therapy provided no major improvement in outcome; here, alternative chemotherapeutic regimens should be tested in a large, randomized, clinical trial to evaluate their efficacy and determine the frequency of delayed toxicity.
Keywords
Medicine
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