Long-term potentiation and depression in hippocampal slices

Experimental NeurologyPublished 1 March 1986

Susan Pockett, O. C. J. Lippold

DOI10.1016/0014-4886(86)90046-4

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Citations21

SJR quartileQ1

SJR score1.50

SNIP1.05

TL;DR

It was found that stimulation via synapses with the same pattern of stimuli caused long-term potentiation in normal conditions but not in the presence of 25 mM Mg2+.

Abstract

Antidromic stimulation of hippocampal CA 1 cells, in the presence of Mg2+ to eliminate synaptic transmission and with a pattern of impulses which when applied via a synaptic pathway produced long-term potentiation, was found to decrease the response of the CA 1 cells to subsequent synaptic activation. It was found that stimulation via synapses with the same pattern of stimuli caused long-term potentiation in normal conditions but not in the presence of 25 mM Mg2+.

Keywords

NeuroscienceBiochemistry, Genetics and Molecular Biology

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The after‐effects of repetitive stimulation of the perforant path fibres to the dentate area of the hippocampal formation have been examined with extracellular micro‐electrodes in rabbits anaesthetized with urethane.

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