Steroids in idiopathic pulmonary fibrosis: a prospective assessment of adverse reactions, response to therapy, and survival
The American Journal of MedicinePublished 1 March 2001
Kevin Flaherty, Galen B. Toews, Joseph P. Lynch, Ella A. Kazerooni, Barry H. Gross, Robert L. Strawderman
Citations180
SJR quartileQ1
SJR score1.00
SNIP1.04
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TL;DR
Coricosteroid treatment for idiopathic pulmonary fibrosis is associated with substantial morbidity and patients who remain stable or respond to corticosteroid therapy have better survival than those who fail to respond.
Abstract
Corticosteroid treatment for idiopathic pulmonary fibrosis is associated with substantial morbidity. Patients who remain stable or respond to corticosteroid therapy have better survival than those who fail to respond. Whether this difference reflects an effect of treatment or less severe disease can be determined only in a randomized trial.
Keywords
Medicine
Journal of the American Statistical AssociationThe Robust Inference for the Cox Proportional Hazards Model
2,480 Citations1989D. Y. Lin, L. J. Wei
Journal of the American Statistical AssociationCounting Processes and Survival Analysis.
2,312 Citations1992Dorota M. Dabrowska, Thomas R. Fleming +1 more
Journal of Occupational and Environmental MedicineSpirometric Standards for Healthy Nonsmoking Adults
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PubMedNormal standards for an incremental progressive cycle ergometer test.
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The VO2 increased linearly with power throughout the test; in an individual subject, the intercept of this relationship was positively influenced by weight and height, and the maximal tidal volume was related to vital capacity.
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The high risk for peptic ulcer disease associated with combined use of NSAIDs and corticosteroids indicates the need to prescribe this drug combination cautiously.
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The AMFM is an objective quantitative method that can be adapted for successful discrimination of multiple parenchymal lung diseases and was significantly better than the MLD and HIST methods.
PubMedStandardized single breath normal values for carbon monoxide diffusing capacity.
491 Citations1981Robert O. Crapo, Alan H. Morris
Prediction equations for DLCO and diffusing capacity per unit of lung volume (DL/VA) were generated from 245 normal subjects using a standardized technique for measuring DLCO using standard and robust regression techniques, predicting values that were higher than most previously reported values.
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461 Citations1997Ella A. Kazerooni, Fernando J. Martínez +8 more
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The data suggest that this CRP score is useful for the estimation of the severity of underlying pathologic derangement and for the longitudinal quantitative assessment of clinical impairment in patients with IPF.
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Data from the New Mexico ILD Registry and from other researchers suggest that the paucity of useful clinical data in IPF has resulted in a hodgepodge of diagnostic approaches and therapeutic criteria, as well as a fatalistic approach to treatment.
BMJChronic Diffuse Interstitial Fibrosis of the Lungs
131 Citations1960J. G. Scadding
A group in which widespread lung changes characterized by the progressive development of fibrosis in the interstitial tissue of the lung cannot be explained as the result of an otherwise recognized pathological process is discussed.
CHEST JournalInterstitial Lung Disease
119 Citations1996
In interstitial lung disease, inflammation, scarring or fibrosis thickens the interstitium, making the lung thick and restricted from filling to their normal capacity and preventing oxygen from passing freely into the bloodstream.
American Review of Respiratory DiseaseQuantitative Assessment of Lung Pathology in Idiopathic Pulmonary Fibrosis
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A model is proposed of the CT appearances in interstitial lung disease based on Weibel's divisions, which shows that prominent nodularity was a feature of lymphangitic carcinomatosis and of the granulomatous diseases, silicosis and sarcoid.
American Journal of Respiratory and Critical Care MedicineInterstitial Lung Disease: A Diagnostic Approach. Are CT Scan and Lung Biopsy Indicated in Every Patient?
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American Journal of Respiratory and Critical Care MedicineCorrelation of structure and function in idiopathic pulmonary fibrosis.
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This study evaluated whether pulmonary function assessment would help distinguish between the cellular and fibrotic phases of this disorder, as determined by a semiquantitative pathology scoring system that comprised four factor scores: fibrosis, cellularity, granulation/connective tissue, and desquamation.
The Medical Journal of AustraliaSide‐effects of corticosteroid agents
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A detailed knowledge of the long-term side-effects of corticosteroid agents and their incidence will assist the physician in making informed judgements on the potential benefits of treatment with these drugs.
Developments in critical care medicine and anestesiologyRespiratory Function Tests
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The purpose of this chapter is to provide a simple explanation of the clinical implications of the most commonly measured respiratory function tests.
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28 Citations1996M K Sridhar
PubMed[Idiopathic diffuse interstitial lung disease].
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JAMACorticosteroid Treatment of Diffuse Interstitial Pulmonary Fibrosis
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