Electrophysiological changes in the surrounding brain tissue of photochemically induced cortical infarcts in the rat
Neuroscience LettersPublished 1 May 1993
R. Domann, Georg Hagemann, Matthias Kraemer, Hans‐Joachim Freund, Otto W. Witte
Citations101
SJR quartileQ2
SJR score0.77
SNIP0.67
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TL;DR
Small infarctions in the parietal cortex of Wistar rats were produced photochemically using the Rose Bengal technique and paired-pulse inhibition was significantly reduced or even absent within an area extending up to 5 mm lateral from the lesion center.
Abstract
Small infarctions in the parietal cortex of Wistar rats were produced photochemically using the Rose Bengal technique. The infarctions evoked reproducible cortical lesions of about 2 mm diameter. In the surrounding brain tissue changes in electrophysiological responses occurred. Whereas in control animals a paired-pulse inhibition could be evoked all over the neocortex, in infarcted animals the paired-pulse inhibition was significantly reduced or even absent within an area extending up to 5 mm lateral from the lesion center. The changes in paired-pulse inhibition were already present on the first day and persisted at least up to 60 days after infarction. These functional changes may contribute to neurological deficits occurring after cerebral infarcts.
Keywords
NeuroscienceBiochemistry, Genetics and Molecular Biology
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