Stress as a predictor of symptomatic genital herpes virus recurrence in women with human immunodeficiency virus
Journal of Psychosomatic ResearchPublished 1 March 2003
Deidre Pereira, Michael H Antoni, Aimee Danielson, Trudi Simon, JoNell Efantis-Potter, Charles S. Carver
Citations42
SJR quartileQ1
SJR score1.31
SNIP1.10
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
It is suggested that stress may be a significant predictor of genital herpes recurrence in women with HIV and HSV-2, and stress management interventions may buffer HSv-related morbidity and mortality in womenwith HIV.
Abstract
These findings suggest that stress may be a significant predictor of genital herpes recurrence in women with HIV and HSV-2. Stress management interventions may buffer HSV-related morbidity and mortality in women with HIV.
Keywords
Medicine
Clinical Infectious Diseases1993 Revised Classification System for HIV Infection and Expanded Surveillance Case Definition for AIDS Among Adolescents and Adults
4,356 Citations1993K. G. Castro, Jill Ward +5 more
The classification system for HIV infection is revised to emphasize the clinical importance of the CD4+ T-lymphocyte count in the categorization of HIV-related clinical conditions and the AIDS surveillance case definition is expanded.
Journal of Consulting and Clinical PsychologyAssessing the impact of life changes: Development of the Life Experiences Survey.
2,456 Citations1978Irwin G. Sarason, James H. Johnson +1 more
New England Journal of MedicineA Seroepidemiologic Survey of the Prevalence of Herpes Simplex Virus Type 2 Infection in the United States
456 Citations1989Robert E. Johnson, André J. Nahmias +4 more
It is concluded that the prevalence of HSV-2 infection in the United States is higher than has previously been recognized and that many infections with this sexually transmitted virus may be subclinical.
Psychosomatic MedicinePosttraumatic Stress Symptoms, Intrusive Thoughts, Loss, and Immune Function after Hurricane Andrew
435 Citations1997Gail Ironson, Christina Wynings +10 more
Loss was a key correlate of both posttraumatic symptoms and immune measures, and evidence was found for new onset of sleep problems as a mediator of the posttraumatic symptom - NKCC relationship.
Annals of Internal MedicineHerpes Simplex Virus Resistant to Acyclovir
369 Citations1990Janet A. Englund, Mark E. Zimmerman +4 more
Herpes simplex virus resistant to acyclovir arises relatively frequently in immunocompromised patients and may cause serious disease and the importance of resistant isolates in hospitalized patients is highlighted.
American Journal of PsychiatryImpact of Stressful Life Events, Depression, Social Support, Coping, and Cortisol on Progression to AIDS
342 Citations2000Jane Leserman, John M. Petitto +7 more
Faster progression to AIDS was associated with higher cumulative average stressful life events, coping by means of denial, and higher serum cortisol as well as with lower cumulative average satisfaction with social support and tobacco use, risky sexual behavior.
JAMAFrequent Recovery of HIV-1 From Genital Herpes Simplex Virus Lesions in HIV-1–Infected Men
311 Citations1998Timothy W. Schacker
HIV-1 virions can consistently be detected in genital ulcers caused by HSV-2, which suggests that genital herpes infection likely increases the efficiency of the sexual transmission of HIV-1.
NatureInduction of CD4 and susceptibility to HIV-1 infection in human CD8+ T lymphocytes by human herpesvirus 6
262 Citations1991Paolo Lusso, Andrea De Maria +5 more
It is demonstrated that human CD3+CD4−CD8+ T lymphocytes can reacquire CD4 in the post-thymic life and a novel mechanism—receptor regulation—through which HHV-6 may positively interact with HIV-1 in coinfected patients is elucidated.
The Journal of Infectious DiseasesThe Impact of Active Herpes Simplex Virus Infection on Human Immunodeficiency Virus Load
236 Citations1997L Molé, Stefan Ripich +2 more
An acute HSV episode can result in increased HIV transcription and plasma virus load, and intracellular HIV gag mRNA increased during the outbreak as well.
JAMAGenital Herpes and Public Health
235 Citations2000Lawrence Corey, H. Hunter Handsfield
Doctors and patients must be aware of the subclinical presentation of genital herpes and the potential these patients have for transmitting HSV, and researchers must evaluate the performance of type-specific tests and strategies to prevent transmission.
Annals of Internal MedicineIncreased Genital Shedding of Herpes Simplex Virus Type 2 in HIV-Seropositive Women
218 Citations1995Michael Augenbraun, Joseph Feldman +6 more
The prevalence of HSV genital shedding in a sample of women who were HIV-seropositive and HSV-2-seropsitive and to compare it with that found in a control group of HIV-serving women were sought, as well as the relation between immune status and shedding rates.
Journal of Consulting and Clinical PsychologyCognitive–behavioral stress management decreases dysphoric mood and herpes simplex virus-Type 2 antibody titers in symptomatic HIV-seropositive gay men.
146 Citations1997Susan K. Lutgendorf, Michael H. Antoni +8 more
The CBSM intervention significantly decreased self-reported dysphoria, anxiety, and total distress and decreased herpes simplex virus-Type 2 (HSV-2) immunoglobulin G antibody titers.
Proceedings of the National Academy of SciencesSevere genital herpes infections in HIV-infected individuals with impaired herpes simplex virus-specific CD8 <sup>+</sup> cytotoxic T lymphocyte responses
144 Citations1997Christine M. Posavad, David M. Koelle +2 more
Quantitative differences in pCTL frequency to HSV appear to be the most important host factor influencing the frequency and severity of HSV reactivation in HIV+ patients, and studies to reconstitute such immunity appear warranted.
Brain Behavior and ImmunityStress-induced suppression of herpes simplex virus (HSV)-specific cytotoxic T lymphocyte and natural killer cell activity and enhancement of acute pathogenesis following local HSV infection
137 Citations1991Robert H. Bonneau, John F. Sheridan +2 more
Evidence is provided that physiological changes associated with restraint stress can influence the immune response to a specific viral infection and alter the course of viral pathogenesis.
American Journal of PsychiatryRelation of stressors and depressive symptoms to clinical progression of viral illness
125 Citations1996Eric P. Zorrilla, James R. McKay +2 more
Depressive symptoms, but not stressors, increase the risk of HSV recurrence generally and do not appear to accelerate HIV progression ubiquitously, although they are associated with increased reporting of HIV-related symptoms.
Psychosomatic MedicineReductions in Herpes Simplex Virus Type 2 Antibody Titers After Cognitive Behavioral Stress Management and Relationships With Neuroendocrine Function, Relaxation Skills, and Social Support in HIV-Positive Men
102 Citations2000Stacy Cruess, Michael H. Antoni +8 more
Findings suggest that behavioral and psychosocial changes occurring during CBSM interventions, including relaxation, enhanced social support, and adrenal hormone reductions, may help to explain the effects of this form of stress management on immune indices such as HSV-2 antibody titers.
American Journal of Obstetrics and GynecologyPrevalence and incidence of gynecologic disorders among women infected with human immunodeficiency virus
93 Citations1999Howard Minkoff, Debra Eisenberger-Matityahu +3 more
Women infected with the human immunodeficiency virus are significantly more likely to have prevalent and incident gynecologic disorders but not disorders related to risk taking (eg, incident sexually transmitted diseases); the latter disorders increased in women with CD4(+) cell counts >500 cells/mm3.
Archives of Internal MedicinePersistent Stress as a Predictor of Genital Herpes Recurrence
90 Citations1999Frances Cohen, Margaret E. Kemeny +4 more
Journal of VirologyHigh frequency of CD8+ cytotoxic T-lymphocyte precursors specific for herpes simplex viruses in persons with genital herpes
88 Citations1996Christine M. Posavad, David M. Koelle +1 more
The results suggest that CD8+ CTL are important effector cells in resolving HSV lesions, and major histocompatibility complex-restricted HSV-specific pCTL were found in 10 consecutively tested HSV type 1- and 2-seropositive subjects.
Medical HypothesesStress-associated immunomodulation and herpes simplex virus infections
79 Citations2001Bruno Sáinz, Jeannette M. Loutsch +2 more
It is suggested that the release of immunomodulating signal molecules due to stress can compromise the host's cellular immune response and trigger herpes simplex viral reactivation.
Sexually Transmitted DiseasesLower Genital Tract Infections Among HIV-Infected and High-Risk Uninfected Women
70 Citations1999Ruth M. Greenblatt, Peter Bacchetti +8 more
HIV+ women were more likely than HIV- women to report previous genital tract infections and symptoms, however, the HIV+ women reported less recent sexual activity and few gonococcal or chlamydial infections.
Health PsychologyThe relationship among genital herpes simplex virus, stress, and social support.
45 Citations1988Cal VanderPlate, Sevgi O. Aral +1 more
The Journal of Infectious DiseasesSexually Transmitted Disease Acquisition among Women Infected with Human Immunodeficiency Virus Type 1
43 Citations1998Susan Bersoff‐Matcha, Mary Horgan +3 more
In 143 HIV-infected women enrolled in a university-based longitudinal HIV clinic over 16 months (mean), the STD point prevalence was examined at enrollment and the cumulative prevalence was calculated at follow-up.
Sexually Transmitted InfectionsPrevalence and risk factors of HSV-1 and HSV-2 antibodies in European HIV infected women
42 Citations2001Birgit van Benthem
The International Journal of Psychiatry in MedicinePsychosocial Factors and Recurrent Genital Herpes: A Review of Prediction and Psychiatric Treatment Studies
37 Citations1993David J. Longo, K Koehn
Psychosocial treatment should be considered as adjunctive therapy for biological treatment of recurrent HSV infections, and the effectiveness of psychological treatment regimes may be explained via psychoimmunological theory.
Psychoneuroimmunology, Stress, and Infection
36 Citations2020Herman Friedman, Thomas Klein +1 more
Brain and Immune Interactions-Historical Perspectives of Psychoneuroimmunology, R.M. Ader and M. Herberman.
Journal of Psychosomatic ResearchPsychosocial factors affecting genital herpes recurrences: Linear vs mediating models
33 Citations1989David J. Longo, George A. Clum
Linear predictive models appear to offer a better opportunity for understanding how psychosocial factors affect genital herpes outbreaks than do interactive or buffering models.
American Psychological Association eBooksInnovative approaches to health psychology: Prevention and treatment lessons from AIDS.
27 Citations2002
Sexually Transmitted InfectionsLate Congenital Syphilis: AN ANALYSIS OF 115 CASES
15 Citations1950Steven Laird
The clinical course and manifestations of an infection are subject to modification over the years, variations in virulence of the infective agent, changes in the immunity or resistance of the population at risk, earlier diagnosis, and more effective treatment are some of the factors responsible for this phenomenon.
Medical Clinics of North AmericaVIRAL INFECTIONS IN HUMAN IMMUNODEFICIENCY VIRUS DISEASE
14 Citations1997Winston Cavert
Further therapeutic advances for some of these viral superinfections, particularly CMV, HSV, VZV, HHV-8, and human genital papillomavirus, will considerably improve the longevity and quality of life of persons with AIDS.
Psychology and HealthPsychoimmunology and aids: Psychological distress and herpes simplex virus in human immunodeficiency virus infected individuals
10 Citations1993Kevin R. Robertson, Jean Wilkins +6 more
Herpes Virus Infections and Psychoneuroimmunology
3 Citations2020Susan Kennedy