Sleep Apnea and Metabolic Dysfunction: Cause or Co-Relation?
Sleep Medicine ClinicsPublished 1 June 2007
R. Nisha Aurora, Naresh M. Punjabi
Citations27
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SJR score1.47
SNIP1.47
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3,657 Citations1999Karine Spiegel, Rachel Leproult +1 more
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PubMedClinical Guidelines on the Identification, Evaluation, and Treatment of Overweight and Obesity in Adults--The Evidence Report. National Institutes of Health.
2,736 Citations1998Anna Meiliana, Andi Wijaya
Journal of Clinical InvestigationSympathetic neural mechanisms in obstructive sleep apnea.
2,499 Citations1995Virend K. Somers, Mark Eric Dyken +2 more
Pharmacological ReviewsThe Sympathetic Nerve—An Integrative Interface between Two Supersystems: The Brain and the Immune System
2,238 Citations2000Ilia J. Elenkov, Ronald L. Wilder +2 more
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NatureProtection from obesity-induced insulin resistance in mice lacking TNF-α function
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Nature MedicineDiet-induced insulin resistance in mice lacking adiponectin/ACRP30
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Journal of Clinical InvestigationMechanism of free fatty acid-induced insulin resistance in humans.
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1,103 Citations2004N.M. Punjabi
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450 Citations1999Kazuo Chin, Kouichi Shimizu +8 more
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The BP oscillations that occur with apnea during sleep may in part be mediated by intermittent surges of sympathetic activity resulting in vasoconstriction because the MSNA responses to obstructive apnea are blunted during O2 administration and appear to be linked to intermittent arterial hypoxemia and stimulation of arterial chemoreceptors.
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Journal of Clinical InvestigationAn in vivo and in vitro study of the mechanism of prednisone-induced insulin resistance in healthy subjects.
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RespirationThe Effect of Continuous Positive Airway Pressure Treatment on Insulin Sensitivity in Patients with Obstructive Sleep Apnoea Syndrome and Type 2 Diabetes
220 Citations2004Igor Alexander Harsch, Simin Pour Schahin +7 more
The results indicate that OSA itself is an independent risk factor for insulin resistance, and this effect may be explained by the elevated sympathetic activity in OSA.
American Journal of Respiratory and Critical Care MedicineHypoxia Causes Glucose Intolerance in Humans
218 Citations2004Kerstin M. Oltmanns, Hartmut Gehring +7 more
Glucose intolerance was closely comparable between hypoxic and hypoglycemic conditions (p < 0.9) despite clear differences in stress hormonal responses.
The Journal of PediatricsMetabolic correlates with obstructive sleep apnea in obese subjects
212 Citations2002Roland C. de la Eva, Louise A. Baur +2 more
The severity of OSA (log(10)RDI) correlated with fasting insulin levels, independent of BMI, and insulin levels may be further elevated as a consequence of Osa in obese children.
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