Physiological Analysis of Skeletal Muscle Weakness and Fatigue
Clinical SciencePublished 1 May 1978
R. H. T. Edwards
Citations157
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Other| May 01 1978 Physiological Analysis of Skeletal Muscle Weakness and Fatigue R. H. T. Edwards R. H. T. Edwards Professor 1Department of Human Metabolism, University College Hospital Medical School, University of London Search for other works by this author on: This Site PubMed Google Scholar Clin Sci Mol Med (1978) 54 (5): 463–470. https://doi.org/10.1042/cs0540463 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Cite Icon Cite Get Permissions Citation R. H. T. Edwards; Physiological Analysis of Skeletal Muscle Weakness and Fatigue. Clin Sci Mol Med 1 May 1978; 54 (5): 463–470. doi: https://doi.org/10.1042/cs0540463 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsClinical Science Search Advanced Search © 1978 The Biochemical Society and the Medical Research Society1978 Article PDF first page preview Close Modal You do not currently have access to this content.
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MedicineEngineering
The Journal of PhysiologyVoluntary strength and fatigue
1,419 Citations1954P A Merton
The paper shows that a maximal voluntary effort develops the same tension as a maximal tetanus artificially excited; in the second part the same equality is found to persist during fatigue, implying that in fatigue, too, the limitation of strength is peripheral.
The Journal of PhysiologyThe orderly recruitment of human motor units during voluntary isometric contractions
924 Citations1973H S Milner‐Brown, R. B. Stein +1 more
The contractile properties of human motor units from the first dorsal interosseus muscle of the hand were studied during voluntary isometric contractions using recently developed techniques.
The Journal of PhysiologyFatigue of long duration in human skeletal muscle after exercise.
771 Citations1977R. H. T. Edwards, D. K. Hill +2 more
The long‐lasting element of fatigue is not due to depletion of high‐energy phosphate nor is it due to failure of electrical activity as recorded from surface electrodes, but is probably the result of an impairment of the process of excitation‐contraction coupling.
The Journal of PhysiologyCapillary supply of the quadriceps femoris muscle of man: adaptive response to exercise
741 Citations1977P. H. Andersen, Jan Henriksson
Five subjects trained for 8 weeks on a bicycle ergometer for an average of 40 min/day, four times a week at a work load requiring 80% of the maximal oxygen uptake, and muscle biopsies were taken before, as well as repeatedly during, the training period.
The Journal of PhysiologySelective glycogen depletion pattern in human muscle fibres after exercise of varying intensity and at varying pedalling rates
644 Citations1974P. D. Gollnick, K. Piehl +1 more
Glycogen depletion pattern in human skeletal muscle fibres was studied after bicycle exercise of varying intensity performed at different pedalling rates.
Journal of Applied PhysiologyForce-velocity relations and fiber composition in human knee extensor muscles
578 Citations1976Alf Thorstensson, Gunnar Grimby +1 more
Standardized measurements of dynamic strength of the kneee extensor muscles were performed in 25 healthy male subjects by means of isokinetic contractions, i.e., knee extensions with constant angular velocities, and correlations were demonstrated between peak torque produced at the highest speed of muscle shortening and percent and relative area of fast twitch fibers in the contracting muscle.
Acta Physiologica ScandinavicaMetabolic Characteristics of Fibre Types in Human Skeletal Muscle
577 Citations1975Birgitta Essén, Eva Jansson +3 more
It is concluded that contractile and metabolic characteristics of human skeletal fibres are very similar to many other species, however, one difference appears to be than no Type II fibres have an oxidative potential higher than Type I fibres.
European Journal of Applied PhysiologyCalculation of muscle strength per unit cross-sectional area of human muscle by means of ultrasonic measurement
555 Citations1968Michio Ikai, Tetsuo Fukunaga
The ultrasonic method used in this work was possibly admitted as the best way to calculate the cross-sectional area of the muscle.
Pflügers Archiv - European Journal of PhysiologyThe time course of phosphorylcreatine resynthesis during recovery of the quadriceps muscle in man
523 Citations1976Roger C. Harris, R. H. T. Edwards +4 more
Occlusion of the circulation to the quadriceps completely abolished the resynthesis of PC and Restoration of resynthesis occurred only after release of occlusion.
Clinical ScienceHuman Skeletal Muscle Function: Description of Tests and Normal Values
497 Citations1977R. H. T. Edwards, A. Young +2 more
Studies of the function of these two muscles are complementary since quadriceps femoris is amenable to needle biopsy investigations of its structure and chemistry whereas adductor pollicis is more suitable for electrophysiological studies.
Clinical ScienceCentral and Peripheral Fatigue in Sustained Maximum Voluntary Contractions of Human Quadriceps Muscle
415 Citations1978B. Bigland-Ritchie, David A. Jones +2 more
It is concluded that in sustained maximum voluntary contractions of the quadriceps central fatigue may account for an appreciable proportion of the force loss, and surface EMG recordings provide no evidence that neuromuscular junction failure is the limiting factor determining the loss of force in this muscle.
The Journal of PhysiologyMotor unit activity in the voluntary contraction of human muscle
349 Citations1954Brenda Bigland, O. C. J. Lippold
The Journal of PhysiologyFatigue of maintained voluntary muscle contraction in man
318 Citations1972John A. Stephens, Anthony R. Taylor
The mechanism of fatigue has been studied in maintained maximal voluntary contractions of the first dorsal interosseous muscle of the hand and the results show that these contractions are associated with fatigue in mice.
Journal of Applied PhysiologyBiochemical adaptation of human skeletal muscle to heavy resistance training and immobilization
313 Citations1977J. D. MacDougall, G. R. Ward +2 more
It was concluded that heavy-resistance training results in increases in muscle energy reserves which may be reversed by a period of immobilization-induced disuse.
The Journal of PhysiologyFiring rate and recruitment order of toe extensor motor units in different modes of voluntary conraction.
306 Citations1977Lennart Grimby, Jan Hannerz
It is suggested that continuously firing low frequency motor units havetype I muscle fibres and intermittently firing high frequency units have type II muscle fibre and that the order of recruitment and the relative roles of the two motor unit types are adapted to the mode of contraction.
European Journal of Applied PhysiologyA study on training effect on strength per unit cross-sectional area of muscle by means of ultrasonic measurement
207 Citations1970Michio Ikai, Tetsuo Fukunaga
The increase of maximum strength was associated with the increase in cross-sectional area and the increaseIn strength per unit cross-section area.
The Journal of PhysiologyChanges in motor commands, as shown by changes in perceived heaviness, during partial curarization and peripheral anaesthesia in man
204 Citations1977Simon C. Gandevia, D.I. McCloskey
The centrally generated ‘effort’ or direct voluntary command to motoneurones required to lift a weight was studied using a simple weight‐matching task when the muscles lifting a reference weight were weakened.
The Journal of PhysiologySelective glycogen depletion in skeletal muscle fibres of man following sustained contractions
194 Citations1974P. D. Gollnick, J. Karlsson +2 more
The isometric exercise consisted of efforts to extend the knee when flexed at an angle of 90° and involved sustained contractions with different tensions related to their maximal voluntary contraction (MVC).
Naunyn-Schmiedeberg s Archives of PharmacologyExcitation-contraction uncoupling in skeletal muscle by dantrolene sodium
161 Citations1972K.O. Ellis, S. H. Bryant
It is concluded that dantrolene sodium has no effect on the electrical excitability of the muscle and uncouples excitation-contraction mechanisms.
Clinical ScienceFunctional and Structural Changes after Disuse of Human Muscle
140 Citations1977A. J. Sargeant, C. T. M. Davies +3 more
The discrepancy between the magnitude of the difference observed in the gross measurement of leg function (maximum oxygen uptake) and structure (leg volume) as compared with the cellular level (cross-sectional fibre area) is discussed.
Archives of Disease in ChildhoodMeasurements of muscle strength and performance in children with normal and diseased muscle.
107 Citations1976Jonathan Hosking, U S Bhat +2 more
The LancetPERCUTANEOUS NEEDLE-BIOPSY OF SKELETAL MUSCLE IN DIAGNOSIS AND RESEARCH
78 Citations1971R. H. T. Edwards
The LancetPERCUTANEOUS NEEDLE BIOPSY IN THE DIAGNOSIS OF MUSCLE DISEASES
64 Citations1973R. H. T. Edwards, P.D. Lewis +2 more
Percutaneous needle biopsy of skeletal muscle can be used in the diagnosis of muscle disease and offers a number of advantages over open biopsy, including the study of the course of a disease, the response to treatment, the early diagnosis of systemic disease, and the investigation of carriers.
The LancetNEEDLE BIOPSY FOR MUSCLE CHEMISTRY
53 Citations1975R. H. T. Edwards, C. A. Maunder +2 more
The methods of analysis, the normal ranges for muscle contents of metabolites and electrolytes, and the reported changes in a number of neuromuscular and metabolic disorders are given.
The American Journal of MedicineDisorder of muscle contraction processes in sex-linked (Duchenne) muscular dystrophy, with correlative electromyographic study of myopathic involvement in small hand muscles
48 Citations1968John E. Desmedt, B Emeryk
The adductor pollicis muscle was investigated by needle electromyography and by nerve stimulation methods in six normal boys serving as controls, and in seventeen hands of fifteen patients with Duchenne muscular dystrophy, providing a quantitative reference base for correlative biochemical, pathophysiologic and electron microscopic studies of the still unknown etiology of this disorder.
Clinical ScienceA Study of the Contractility, Biochemistry and Morphology of an Isolated Preparation of Human Skeletal Muscle
41 Citations1977R. F. W. Moulds, A. Young +2 more
The isolated preparations were found to have the same contractile properties as human quadriceps femoris studied in vivo by the methods described in the preceeding paper.
Journal of Neurology Neurosurgery & PsychiatryIsometric contraction of the abductor digiti minimi muscle in man
40 Citations1974David Burke, Nevell F. Skuse +1 more
The results suggest that there is a homogeneous group of motor units in ADM (with respect to contraction time) and that this group contains what are probable fast twitch fatigue sensitive and fatigue resistant motor units.
Clinical ScienceAnalysis of Muscle Weakness in Osteomalacia
31 Citations1978A. Young, D. P. Brenton +1 more
Archives of Disease in ChildhoodTests of skeletal muscle function in children.
20 Citations1978G Hosking, A. Young +2 more
In normal children a number of indices of muscle function were found to be similar to those in adults, and a small study of the function of the adductor pollicis using supramaximal stimulation of the ulnar nerve was carried out in boys with Duchenne dystrophy.
The LancetWEAKNESS IN MYOTONIC SYNDROMES
18 Citations1977C. M. Wiles, R. H. T. Edwards
In individual myotonic disorders the ability to identify the origin of the muscle weakness and the functional level at which the defect occurs would assist the choice of rational treatment.
British Journal of PharmacologyA COMPARISON OF THE EFFECTS OF SODIUM THIOCYANATE AND DANTROLENE SODIUM ON A MAMMALIAN ISOLATED SKELETAL MUSCLE
15 Citations1977R. F. W. Moulds
It is concluded that the mechanism of action of dantrolene is by inhibition of the release of the calcium ions involved in the ECC mechanism, probably at the level of the transverse tubules.
Lara D. VeekenCLINICAL INVESTIGATIONS OF MUSCLE CONTRACTILITY
4 Citations1977Angela Young, R. H. T. Edwards
The in vivo testing of a drug's pharmacological activity on the quadriceps muscle is described by a study of the relative forces produced by different frequencies of stimulation and it is illustrated that hypothyroidism is not the only endocrine disorder whose treatment may be monitored by measuring the speed of muscle relaxation.
PubMedClinical assessment of skeletal muscle function
3 Citations1978R. H. T. Edwards
A systematic clinical analysis of skeletal muscle function is presented, providing a possible basis for recognising the functional disorder and for evaluating the effects of physiotherapy and drug treatments in patients with neuromuscular disorders.