Reduced startle reactivity and plasticity in transgenic mice overexpressing corticotropin-releasing hormone
Biological PsychiatryPublished 1 April 2002
Anneloes Dirks, Lucianne Groenink, Marlies Iutje Schipholt, Jan van der Gugten, Theo H. Hijzen, Mark A. Geyer
Citations83
SJR quartileQ1
SJR score4.68
SNIP2.24
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TL;DR
Chronic CRH excess may reduce behavioral reactivity to environmental stimuli and impair information processing mechanisms, as indicated by results in CRH-OE(2122) mice.
Abstract
The results in CRH-OE(2122) mice indicate that chronic CRH hyperactivity is associated with reductions in startle reactivity, habituation, and prepulse inhibition. The latter two abnormalities are also observed in schizophrenia patients. We conclude that chronic CRH excess may reduce behavioral reactivity to environmental stimuli and impair information processing mechanisms.
Keywords
MedicineNeuroscience
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