Oxidative C–H/C–H Coupling of Azine and Indole/Pyrrole Nuclei: Palladium Catalysis and Synthesis of Eudistomin U
Chemistry LettersPublished 21 April 2011
Atsushi Yamaguchi, Debashis Mandal, Junichiro Yamaguchi, Kenichiro Itami
Citations126
SJR quartileQ3
SJR score0.37
SNIP0.40
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Abstract
Abstract We have developed a palladium-catalyzed C–H/C–H coupling reaction of indoles or pyrroles with azine N-oxides. The reaction proceeds selectively at the C3 position of indoles/pyrroles and the C2 position of azine N-oxides. Furthermore, we have accomplished the synthesis of marine indole alkaloid eudistomin U by utilizing this newly developed C–H/C–H coupling reaction.
Keywords
ChemistryBiochemistry, Genetics and Molecular Biology
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