Thermogenesis in Muscle
Annual Review of PhysiologyPublished 1 October 1994
Barbara A. Block
Citations278
SJR quartileQ1
SJR score7.82
SNIP4.62
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
This review examines skeletal muscle in light of its secondary role as a furnace and the fundamental mechanisms for heat generation without contractile activity have not been elucidated.
Abstract
Mitochondrial fatty acid β-oxidation (FAO) is the major pathway for the degradation of fatty acids and is essential for maintaining energy homeostasis in the human body. Fatty acids are a crucial energy source in the postabsorptive and fasted states when ...Read More
Keywords
Agricultural and Biological SciencesMedicineBiochemistry, Genetics and Molecular Biology
NatureInositol phosphates and cell signalling
4,073 Citations1989Michael J. Berridge, Robin F. Irvine
The subtlety of calcium regulation by inositol phosphates is emphasized by recent studies that have revealed oscillations in calcium concentration which are perhaps part of a frequency-encoded second-messenger system.
ScienceIdentification of a Mutation in Porcine Ryanodine Receptor Associated with Malignant Hyperthermia
1,493 Citations1991Junichi Fujii, Kinya Otsu +6 more
Haplotyping suggests that the mutation in all five breeds of lean, heavily muscled swine has a common origin, and the development of a noninvasive diagnostic test will provide the basis for elimination of the MH gene or its controlled inclusion in swine breeding programs.
NaturePrimary structure and expression from complementary DNA of skeletal muscle ryanodine receptor
1,137 Citations1989Hiroshi Takeshima, Seiichiro Nishimura +9 more
The predicted structure suggests that the calcium release channel activity resides in the C-terminal region of the receptor molecule, whereas the remaining portion constitutes the 'foot' structure spanning the junctional gap between the sarcoplasmic reticulum and the transverse tubule.
NaturePurification and reconstitution of the calcium release channel from skeletal muscle
934 Citations1988F. Anthony Lai, Harold Erickson +3 more
Ca2+ release from the SR induced by T-system depolarization during excitation-contraction coupling in muscle may be effected through a direct association of the T- system with SR Ca22+-release channels.
Biological reviews/Biological reviews of the Cambridge Philosophical SocietyNON‐SHIVERING THERMOGENESIS AND ITS THERMOREGULATORY SIGNIFICANCE
614 Citations1973L Janský
Non‐shivering thermogenesis is a heat‐production mechanism participating in the chemical thermoregulation of mammals and its role in animal welfare is clarified in 1.1.
NatureRyanodine receptor gene is a candidate for predisposition to malignant hyperthermia
526 Citations1990David H. MacLennan, Catherine Duff +7 more
Co-segregation of MH with RYRmarkers, resulting in a lod score of 4.20 at a linkage distance of zero centimorgans, indicates that MH is likely to be caused by mutations in the RYR gene.
The FASEB JournalBrown adipose tissue thermogenesis: interdisciplinary studies
460 Citations1990Jean Himms‐Hagen
Ext extrapolation to humans of results of studies of BAT requires the development of novel approaches to the noninvasive assessment of amount and function of human BAT.
Trends in NeurosciencesDirect regulation of ion channels by fatty acids
408 Citations1991Richard W. Ordway, J J Singer +1 more
The Hot-Blooded Insects
375 Citations1993Bernd Heinrich
NatureLocalization of the malignant hyperthermia susceptibility locus to human chromosome 19ql2–13.2
374 Citations1990Tommie V. McCarthy, John Healy +6 more
Linkage between MHS and DNA markers from the GPI region of human chromosome 19 with a maximum log likelihood ratio (lod score) of 5.65 indicates that human and porcine MH are most probably due to mutations in homologous genes, and provides a potentially accurate and noninvasive method of diagnosis for MHS.
Journal of Biological ChemistryAdenine nucleotide stimulation of Ca2+-induced Ca2+ release in sarcoplasmic reticulum.
373 Citations1984Gerhard Meissner
Ca2+ flux studies with actively loaded vesicles also indicated that a subpopulation of sarcoplasmic reticulum vesicle contains a Ca2+ permeation system that is activated by adenine nucleotides.
GenomicsA substitution of cysteine for arginine 614 in the ryanodine receptor is potentially causative of human malignant hyperthermia
316 Citations1991Elizabeth F. Gillard, Kinya Otsu +8 more
Analysis of 35 human families predisposed to malignant hyperthermia has revealed the presence, and cosegregation with phenotype, of the corresponding substitution in a single family, which may be causal for predisposition to MH in this family.
Annual Review of PhysiologyCa2+ As a Second Messenger within Mitochondria of the Heart and other Tissues
302 Citations1990Richard M. Denton, J G McCormack
Of the known second-messenger molecules that act within the cytosolic compartment of mammalian cells, it appears that only Ca2+ is transferred into the mitochondrial matrix.
Fishery BulletinDaily patterns in the activities of swordfish, Xiphias gladius, observed by acoustic telemetry
286 Citations1981Francis G. Carey, Bret Robinson
Annual Review of PhysiologyTemperature Acclimation in Birds and Mammals
285 Citations1971R. R. J. Chaffee, J. C. Roberts
This review will be concerned almost entirely with a survey of recent studies on temperature acclimation mechanisms in both birds and mammals, which have received various degrees of emphasis in the last 5 years.
American ZoologistWarm-Bodied Fish
281 Citations1971Francis G. Carey, John M. Teal +3 more
Telemetry experiments show that the bluefin tuna can maintain a constant deep body temperature during marked changes in the temperature of its environment, suggesting the selective advantages of greater speed made possible by the warm muscle were important in the evolution of this system.
ScienceEvolution of Endothermy in Fish: Mapping Physiological Traits on a Molecular Phylogeny
260 Citations1993Barbara A. Block, John R. Finnerty +2 more
A molecular phylogeny of the Scombroidei has been determined by direct sequencing of a portion of the mitochondrial cytochrome b gene and indicates that the ability to warm the brain and retina arose independently in three lineages, each time in association with a movement into colder water.
American Journal of Physiology-Endocrinology and MetabolismCa2+ transport by mammalian mitochondria and its role in hormone action
245 Citations1985R M Denton, J G McCormack
It is argued that the main role of the calcium transport system in mammalian mitochondria is to relay changes in cytoplasmic Ca2+ into the mitochondrial matrix, which could increase intramitochondrial oxidative metabolism and hence promote the replenishment of ATP.
Journal of Biological ChemistryExpression of uncoupling protein mRNA in thermogenic or weakly thermogenic brown adipose tissue. Evidence for a rapid beta-adrenoreceptor-mediated and transcriptionally regulated step during activation of thermogenesis.
234 Citations1986Daniel Ricquier, Frédéric Bouillaud +5 more
Measurement of the relative concentration of nascent UCP transcripts in nuclei isolated from brown adipose tissue indicates that Ucp gene is acutely regulated at the level of transcription and is controlled via activation of beta-adrenoreceptors of plasma membrane.
Journal of Biological ChemistryAbnormal sarcoplasmic reticulum ryanodine receptor in malignant hyperthermia.
234 Citations1988James R. Mickelson, Esther M. Gallant +4 more
It is found that MHS porcine muscle intact fiber bundles exhibit a 5-10-fold lower ryanodine threshold for twitch and tetanus inhibition, and contracture onset when compared to normal muscle, which may be responsible for the abnormal SR calcium release and contractile properties demonstrated by MHS muscle.
Journal of Experimental BiologyOxygen Consumption of Moths During Rest, Pre-Flight Warm-Up, and Flight in Relation to Body Size and Wing Morphology
233 Citations1978George A. Bartholomew, Timothy M. Casey
The sphingids had higher wing loading, aspect ratio, and wing beat frequency during flight than the saturniids, and the scaling of oxygen consumption during flight in the moths is almost identical to that of bats and birds.
Journal of Experimental BiologyPower and efficiency of insect flight muscle
215 Citations1985C. P. Ellington
The efficiency and mechanical power output of insect flight muscle have been estimated from a study of hovering flight and suggest that the muscle efficiency is quite low: less than 10%.
Biophysical JournalAbnormal ryanodine receptor channels in malignant hyperthermia
209 Citations1990Michael Fill, Roberto Coronado +5 more
It is proposed that a defect in a low-affinity Ca2+ binding site is responsible for the altered gating of MHS SR channels, providing a testable hypothesis for the molecular basis of this inherited disorder.
The Journal of General PhysiologyIn Vivo Studies on Fast and Slow Muscle Fibers in Cat Extraocular Muscles
193 Citations1966Paul Bach‐y‐Rita, Fumio Ito
In anesthetized in vivo preparations, responses of two types of extraocular muscle fibers have been studied and the small, multiply innervated slow fibers have be shown to be capable of producing propagated impulses, and thus have been labeled slow multi-innervated twitch fibers.
Proceedings of the National Academy of SciencesMitochondrial respiration in hummingbird flight muscles.
186 Citations1991Raul K. Suarez, John R. B. Lighton +2 more
It is proposed that both mitochondrial volume densities and Sv(im,m) are near their maximum theoretical limits in hummingbirds and that higher rates of mitochondrial respiration than those observed in mammals are achieved in vivo as a result of higher capacities for O2 delivery and substrate catabolism.
Journal of Biological ChemistryIdentification and localization of two triad junctional foot protein isoforms in mature avian fast twitch skeletal muscle.
181 Citations1990Judith A. Airey, Claudia F. Beck +5 more
Two distinct homo-oligomeric foot proteins coexist in avian fast twitch skeletal muscle by using isoform-specific antibodies and being identified as foot proteins.
ScienceA Brain Heater in the Swordfish
175 Citations1982Francis G. Carey
The brain and eye of swordfish are warmer than the water, and a tissue that heats the brain is associated with one of the eye muscles that protects the central nervous system from rapid cooling during daily vertical excursions.
Annual Review of PhysiologyEnergetics and Electrogenicity of the Sarcoplasmic Reticulum Calcium Pump
167 Citations1983W. Hasselbach, H. Oetliker
The energetics of muscular Ca turnover is evaluated from diff erent view points; maintenance and restitution of the resting gradi ent, (b) transformation of chemical into osmotic energy, and (c) membrane permeabilities interfering with passive and active Ca movement are evaluated.
Journal of Comparative Physiology BSeasonal acclimatization to temperature in cardueline finches
163 Citations1976William R. Dawson, Cynthia Carey
Metabolic rather than insulative adjustments appear primarily responsible for the acclimatization of American goldfinches and pine siskins to winter conditions in the northern United States.
European Journal of BiochemistryOxidative Phosphorylation and Compartmentation of Fatty Acid Metabolism in Brown Fat Mitochondria
157 Citations1969K.J. Hittelman, Olle R. Lindberg +1 more
It is concluded that the endogenous substrate of brown fat mitochondria is free fatty acids which lie initially outside the acyl-CoA barrier, and that these are responsible for the uncoupled behavior of the freshly isolated particles.
Journal of Experimental BiologyEffects of operating frequency and temperature on mechanical power output from moth flight muscle
157 Citations1990R. D. Stevenson, Robert K. Josephson
In the tobacco hawkmoth there is a good correspondence between the conditions of temperature and cycle frequency that produce maximal mechanical power output in the muscle preparation and the thoracic temperature and wing beat frequency observed during hovering flight.
Journal of MorphologyStructure of the brain and eye heater tissue in marlins, sailfish, and spearfishes
147 Citations1986Barbara A. Block
An unusual circulatory supply to the eyes and brain is associated with the presence of the heater tissue in these fishes.
Journal of Comparative Physiology BSeasonal acclimatization to temperature in cardueline finches
140 Citations1978Cynthia Carey, William R. Dawson +2 more
Increased stores of body lipid and muscle carbohydrate and the ability to mobilize these substrates rapidly during cold stress seem to be key factors in the superior thermogenic capacities of winter goldfinches.
ScienceTemperature Acclimation: Improved Sustained Swimming Performance in Carp at Low Temperatures
139 Citations1985Lawrence C. Rome, P. T. Loughna +1 more
Results show that, because of changes in the biochemistry and morphology of the aerobic muscle during cold acclimation, carp can swim faster at low temperature using only their aerobic muscle, which results in their sustainable swimming speed.
European Journal of BiochemistryOxidative Metabolism in Cells Isolated from Brown Adipose Tissue
130 Citations1968Stanley B. Prusiner, Barbara Cannon +1 more
Journal of Applied Physiology<i>Cold Acclimation and the Electromyogram of Unanesthetized Rats</i>
129 Citations1956J. S. Hart, O. Héroux +1 more
Shivering measured by the electromyogram was absent in cold acclimated rats at 6°C, indicating that thermogenesis apparently was almost exclusively of the chemical type.
NatureRole of Red and White Muscles in the Swimming of the Skipjack Tuna
126 Citations1967Martin D. Rayner, M. J. KEENAN
Braekkan2, on the basis of a primarily biochemical investigation, has concluded that this deep red muscle functions as a store of energy for the adjacent region of white rather than as a contractile tissue in its own right.
Biodiversity Heritage Library (Smithsonian Institution)Contributions to the comparative study of the so-called Scombroid fishes
123 Citations1923Kamakichi Kishinouye
Canadian Journal of ZoologyMitochondrial metabolism of cardiac and skeletal muscles from a fast (<i>Katsuwonus pelamis</i>) and a slow (<i>Cyprinus carpio</i>) fish
116 Citations1992Christopher D. Moyes, Odile Mathieu‐Costello +2 more
Higher aerobic capacities of tuna ventricle and red muscle are primarily attributable to greater tissue mass and, to a lesser extent, differ from carp tissues, which have less mitochondrial volume densities.
Journal of Comparative Physiology BCatabolic enzyme activities in relation to premigratory fattening and muscle hypertrophy in the gray catbird (Dumetella carolinensis)
109 Citations1981Richard L. Marsh
The flight muscles of the gray catbird were examined to determine if short term adjustments occur in the activity of key catabolic enzymes during preparation for long distance migration to meet the increased power requirements of flight due to the increased body mass.
Journal of Experimental BiologyMalleability of skeletal muscle in overcoming limitations: structural elements
109 Citations1985Hans Hoppeler, Stan L. Lindstedt
It is hypothesized that there is a constant volume of oxygen metabolized per unit volume of mitochondria and unit time under limiting conditions in working skeletal muscle tissue, which would allow an estimate of the potential for aerobic power production of a muscle from measurement of its volume density of mitochondia.
Physiological ZoologySeasonal and Geographic Variation of Cold Resistance in House Finches Carpodacus mexicanus
108 Citations1983William R. Dawson, Richard L. Marsh +2 more
Evidence is assembled suggesting that winter acclimatization is primarily metabolic in captive as well as free-living house finches.
Environmental Biology of FishesUnique adaptations of the metabolic biochemistry of tunas and billfishes for life in the pelagic environment
106 Citations1995Kathryn A. Dickson
There are major gaps in the understanding of the metabolic biochemistry and physiology of these fishes, and these are highlighted so that additional research can be directed towards filling these gaps.
Journal of Muscle Research and Cell MotilityQuantitation of Ca ATPase, feet and mitochondria in superfast muscle fibres from the toadfish,Opsanus tau
93 Citations1991Denah M. Appelt, Vivienne Shen +1 more
It is concluded that calcium uptake is a limiting factor in the ability to sustain the trains of high frequency, non-fused synchronous contractions of which these fibres are capable.
Biophysical JournalNonmammalian vertebrate skeletal muscles express two triad junctional foot protein isoforms
93 Citations1991E.B. Olivares, S.J. Tanksley +6 more
In contrast to mammalian skeletal muscle, two foot protein isoforms are present in amphibian, avian, and piscine skeletal muscles, which may represent a general difference in the architecture and/or a functional specialization of the triad junction in mammalian and nonmammalian vertebrate muscles.
Journal of Experimental BiologyMetabolic Sources of Heat and Power in Tuna Muscles
93 Citations1979M. Guppy, William C. Hulbert +1 more
Metabolite profiles under three different activity states were used to identify which metabolic processes in white and red muscles could account for observed excess temperatures, and interpretations are fully consistent with enzyme profiles of red and white muscles in tuna.
American Journal of Physiology-Cell PhysiologyAmphibian ryanodine receptor isoforms are related to those of mammalian skeletal or cardiac muscle
91 Citations1992F. Anthony Lai, Q. Y. Liu +5 more
The results suggest that amphibian skeletal muscle expresses two distinct RyR isoforms that share epitopes in common with the mammalian skeletal or cardiac RyR.
Comparative Biochemistry and PhysiologySome effects of cold on the metabolism of the fowl during the perinatal period
84 Citations1967B. M. Freeman
Significant falls in hepatic glycogen and blood sugar could be demonstrated in 19-day-old embryos after 60 min exposure to cold and there was evidence that the response was enhanced.
The Journal of PhysiologyMultilocular adipocytes from muscovy ducklings differentiated in response to cold acclimation.
83 Citations1986Hervé Barré, F. Cohen-Adad +2 more
The results confirm the existence of n.s.t. in 6‐week‐old cold‐acclimated muscovy ducklings and typical multilocular adipocytes were found in subcutaneous adipose deposits instead of the unilocular white adipocytes as in control ducklings.
Journal of Experimental BiologyA Synchronous Insect Muscle With an Operating Frequency Greater Than 500 Hz*
80 Citations1985Robert K. Josephson, D. K. Young
The tymbal muscle of O. vanduzeei is indeed a synchronous muscle, albeit a highly modified one, capable of operating at 550 Hz, and it is suggested that the advantages of asynchronous muscles lie chiefly in their greater economy of structure and operation, rather than in an ability to operate at higher frequencies than synchronous muscles.
American Journal of Physiology-Regulatory, Integrative and Comparative PhysiologySubstrate metabolism in seasonally acclimatized American goldfinches
76 Citations1982Richard L. Marsh, William R. Dawson
The ability to restrict carbohydrate use under cold stress is a component of the winter acclimatization process in the American goldfinch, and one mechanism which might foster this ability in the increase in beta-oxidative capacity of the flight muscles, permitting a greater reliance on fatty acids by winter animals during cold-induced thermogenesis.
Journal of Experimental BiologyThe Bidder Lecture, 1980: The Evolution of Fibrillar Muscle in Insects
76 Citations1981J. W. S. Pringle
Fibrillar muscle is a peculiar type of striated muscle found only in the powerproducing flight muscles of certain higher Orders of insects and in the main timbal* muscle of the sound-production system of certain cicadas.
Biophysical JournalThe fastest contracting muscles of nonmammalian vertebrates express only one isoform of the ryanodine receptor
74 Citations1993John O’Brien, Gerhard Meissner +1 more
The appearance of the alpha RYR isoform alone in the extraocular muscles and a fast-contracting sonic muscle in fish (toadfish swimbladder muscle) provides evidence that this isoform is selectively expressed when rapid contraction is required.
The Histochemical JournalA combined histochemical and biochemical study of myofibrillar ATPase in pectoral, leg and cardiac muscle of several species of bird
73 Citations1978G. L. Talesara, G. Goldspink
The results demonstrated that histochemical methods can be applied, with a reasonable degree of confidence, to classifying fibres in avian muscles although the classification used for mammalian muscles needs to be modified.
Comparative Biochemistry and Physiology Part B Comparative BiochemistryIs the “mammalian” brown fat-specific mitochondrial uncoupling protein present in adipose tissues of birds?
73 Citations1991Seppo Saarela, Jacqueline S. Keith +2 more
Canadian Journal of Biochemistry and PhysiologyPARTICIPATION OF SKELETAL MUSCLE AND KIDNEY DURING NONSHIVERING THERMOGENESIS IN COLD-ACCLIMATED RATS
71 Citations1963L Janský, J. S. Hart
Direct evidence for significant participation of striated muscles in non-shivering thermogenesis has thus been obtained, and it appears unlikely that the maximal potential increase in oxygen consumption of cold-acclimated rats at very low temperatures could be attributed solely to the metabolic act.
Cell and Tissue ResearchFine structure and metabolism of multiply innervated fast muscle fibres in teleost fish
69 Citations1981IanA. Johnston, ThomasW. Moon
The results indicate a considerable variation in the aerobic capacities and principal fuels supporting activity among the fast muscles of different species.
Pflügers Archiv - European Journal of PhysiologyRapid rise in plasma glucagon induced by acute cold exposure in man and rat
66 Citations1981Hans Seitz, Wilhelm Krone +5 more
It is concluded that acute cold exposure caused a rapid rise in the concentration of plasma glucagon leading to an increase in the Concentration cycloAMP, thus enhancing the rate of hepatic gluconeogenesis and ketogenesis, and suggested that glucagon may play a role in the metabolic adaptation to acutecold exposure.
The Journal of PhysiologyHistochemical arguments for muscular non‐shivering thermogenesis in muscovy ducklings.
64 Citations1992Claude Duchamp, F. Cohen-Adad +2 more
Because of the higher loose‐coupled state of muscle mitochondria in cold‐acclimated and glucagon‐treated than in control ducklings, the higher oxidative capacity of skeletal muscle in these ducklings could be used for heat production rather than ATP synthesis and account for muscular non‐shivering thermogenesis.
Comparative Biochemistry and Physiology Part B Comparative BiochemistryIncreased respiration in skeletal muscle mitochondria from cold-acclimated ducklings: Uncoupling effects of free fatty acids
62 Citations1986Hervé Barré, Jan Nedergaard +1 more
The increase in respiration due to FFA was about double in intermyofibrillar mitochondria from cold-acclimated ducklings than that of controls, but in liver mitochondria there was no increase due to cold.
Biological BulletinRECORDINGS OF HIGH WING-STROKE AND THORACIC VIBRATION FREQUENCY IN SOME MIDGES
62 Citations1953Olavi Sotavalta
Experiments on recording flight-tones and thoracic vibrations in intact and wing-mutilated midges (Chironomus, Forcipomyia), using double-beam cathoderay oscillograph and film and acoustic method, are reported.
Molecular and Cellular BiochemistryThe role of Ca2+ ions in the regulation of intramitochondrial metabolism and energy production in rat heart
62 Citations1989J G McCormack, RichardM. Denton
It is proposed that the major function of the mitochondrial Ca2-transport system is to regulate matrix Ca2+, and that the ability of mitochondria to buffer the extramitochondrial concentration of Ca2+ may thus only be reserved for pathophysiological conditions of abnormal sarcolemmal Ca 2+ influx as perhaps may occur in ischaemia reperfusion.
Journal of Experimental BiologyThermoregulation by Winter-Flying Endothermic Moths
59 Citations1987Bernd Heinrich
The generation and maintenance of such high thoracic temperatures at low air temperatures depends on the ability to begin shivering at very low muscle temperatures, a thick insulating pile, and counter-current heat exchangers that retard heat flow to the head and to the abdomen, respectively.
The Journal of PhysiologyThe efficiency of a flight muscle from the locust Schistocerca americana.
57 Citations1991Robert K. Josephson, R. D. Stevenson
The efficiency of the metathoracic tergosternal muscle of the locust Schistocerca americana was examined by simultaneously measuring work output from the muscle and oxygen consumption by the muscle.
Metabolic Acclimatization to Cold and Season in Birds
56 Citations1989William R. Dawson, Richard L. Marsh
The goal is to characterize metabolic acclimatization by birds to cold and season to an extent commensurate with current knowledge of this form of compensation.
The Journal of Cell BiologyThe structure of the membrane systems in a novel muscle cell modified for heat production.
56 Citations1988Barbara A. Block, C Franzini-Armstrong
Freeze-fracture studies and negative staining of microsomal fractions treated with vanadate indicate that most of the membrane system of heater cells has a high Ca2+-ATPase density and is equivalent to skeletal muscle sarcoplasmic reticulum (SR).
Cell and Tissue ResearchEffect of cold environment on skeletal muscle mitochondria in growing rats
55 Citations1982Katharina Buser, Bernhard Kopp +3 more
In cold-adapted animals, the total volume of mitochondria was significantly increased by 24% in diaphragm and 37% in M. soleus, whereas the surface of the outer mitochondrial membranes per unit volume of mitochondrialrion was increased only in the subsarcolemmal mitochondria.
The Journal of Cell BiologyTHE ASSOCIATION OF LIPID DROPLETS WITH CYTOPLASMIC FILAMENTS IN AVIAN SUBSYNOVIAL ADIPOSE CELLS
53 Citations1966Louise M. Luckenbill, Alan S. Cohen
Biophysical JournalActivation of the Ca2+ release channel of skeletal muscle sarcoplasmic reticulum by palmitoyl carnitine
52 Citations1993Roque El-Hayek, Carmen R. Valdivia +3 more
This newly identified interaction of esterified fatty acids and ryanodine receptors may represent a pathway by which metabolism of skeletal muscle could influence intracellular Ca2+ and may be responsible for the pathophysiology of disorders of beta-oxidation such as carnitine palmitoyl transferase II deficiency.
Poultry ScienceCold-Acclimation and the Role of Catecholamines in Body Temperature Regulation in Male Leghorns
52 Citations1970Mohamed El-Sayed El Halawani, Wilbor O. Wilson +1 more
It is suggested that the development of nonshivering thermogenesis during cold acclimation involves the reestablishment of the neonatal thermoregulatory mechanism and as far as birds are concerned, there is evidence indicating the existence of such a mechanism.
Advances in comparative and environmental physiologyEffects of Temperature on Muscular Function and Locomotory Performance in Teleost Fish
51 Citations1989Bruce D. Sidell, Timothy S. Moerland
All modes of animal locomotion are variations on a theme in which the organism converts chemical potential energy into the kinetic energy of a moving body.
ScienceFlight of Winter Moths Near 0°C
51 Citations1985Bernd Heinrich, Thomas P. Mommsen
The geometrids that are able to fly with a thoracic temperature near 0�C do so largely because of unusually low wing-loading, which permits a low energetic cost of flight.
American ZoologistEvolutionary Novelties: How Fish Have Built a Heater Out of Muscle
51 Citations1991Barbara A. Block
Interdisciplinary studies, combining the resolving power of molecular biology with the complex problems of organismal biology, will shed new light on whole animal function and evolution.
American Journal of Physiology-Endocrinology and MetabolismTwo daily glucagon injections induce nonshivering thermogenesis in Muscovy ducklings
48 Citations1987Hervé Barré, F. Cohen-Adad +1 more
In the cold, glucagon injection inhibited shivering in both groups of ducklings but thermogenesis was not suppressed in GT ducklings, showing a true nonshivering thermogenesis in these birds.
Journal of Biological ChemistryDistinct immunopeptide maps of the sarcoplasmic reticulum Ca2+ release channel in malignant hyperthermia.
45 Citations1990C. Michael Knudson, James R. Mickelson +2 more
Results can be explained by a primary amino acid sequence difference between the normal and MHS Ca2+ release channels and support the hypothesis that a mutation in the gene coding for the sarcoplasmic reticulum Ca2- release channel is responsible for malignant hyperthermia.
Biological reviews/Biological reviews of the Cambridge Philosophical SocietyPhysiological Responses Of Birds To Flight And Running
45 Citations1984J. H. Brackenbury
The energy required for sustained physical activity in flying and running birds is obtained from fatty acids mobilized from adipose stores under the influence of hormones.
Anesthesia & AnalgesiaA Cysteine-for-Arginine Substitution (R614C) in the Human Skeletal Muscle Calcium Release Channel Cosegregates With Malignant Hyperthermia
43 Citations1992Kirk J. Hogan, Fergus J. Couch +2 more
Findings suggest that the cysteine-for-arginine mutation represents a shared calcium release channel pathogenesis between porcine malignanthyperthermia and a subset of mutations responsible for the human malignant hyperthermia syndrome.
Cell and Tissue ResearchUltrastructure of the different fibre types in axial muscles of the sharks Etmopterus spinax and Galeus melastomus
43 Citations1977Harald Kryvi
Red, intermediate and white axial muscle fibres of the sharks Etmopterus spinax and Galeus melastomus were studied by electron microscopy and morphometry and the morphology is discussed in relation to current views on the functions of different muscle fibre types.
Tissue and CellQuantitative analyses of ultrastructure and vascularization of the slow muscle fibres of the anchovy
42 Citations1982Ian A. Johnston
A quantitative study has been made of the ultrastructure and vascularization of slow fibres in the lateral muscles of the European anchovy and adaptations for increasing the capacity of skeletal muscle for aerobic work are discussed.
Comparative Biochemistry and Physiology Part A PhysiologyDo birds possess brown adipose tissue?
42 Citations1989Seppo Saarela, R. Hissa +4 more
It is shown that AAT in the adult birds resembles white adipose tissue more than brown, and multilocularity of adipocytes may improve lipolysis to deliver fatty acids for muscle fuel of shivering or NST.
Muscle & NerveCarnitine palmitoyl transferase deficiency in malignant hyperthermia
40 Citations1993Georgirene D. Vladutiu, Kirk J. Hogan +3 more
It is likely that a subset of individuals with a malignanthyperthermia phenotype have a primary deficiency of carnitine palmitoyl transferase and that others have a milder enzyme deficiency secondary to the primary defect in malignant hyperthermia.
PubMedOrgan blood flow haemodynamics and metabolism of the albacore tuna Thunnus alalunga (Bonnaterre).
40 Citations1988White Fc, R A Kelly +4 more
These measurements record the albacore's markedly high cardiovascular capability and showed a reverse temperature effect on arterial PO2 and a P50 of 15.9 Torr corrected to 37 degrees C.
Journal of Fish BiologyRed and white muscle fibre activity in swimming skipjack tuna, <i>Katsuwonus pelamis</i> (L.)
40 Citations1979Richard W. Brill, Andrew E. Dizon
To test the hypothesis that white muscle fibre portions of the myotomes are used at sustainable swimming speeds, skipjack tuna, Katsuwonus pelamis, were forced to swim against various current velocities in a water tunnel while electrical activity of the red and white muscle fibres was simultaneously recorded.
Ornithological ApplicationsFirst Observations of Brown Fat in Birds
39 Citations1983Lynn W. Oliphant
Le tissu adipeux de Bonasa umbellus and Parus atricapillus montre les caracteristiques histologiques and ultrastructurales typiques du tissuadipeux brun des mammiferes.
Enzyme Activities in Muscles of Seasonally Acclimatized House Finches
39 Citations1989Cynthia Carey, Richard L. Marsh +3 more
Members of the avian subfamily Carduelinae, including goldfinches, pine siskins, house finches, grosbeaks, crossbills, and redpolls, are particularly well suited for such study because of their principally northern distribution and small body sizes.
Proceedings of the National Academy of SciencesHeat Exchnage in the Black Skipjack, and the Blood-Gas Relationship of Warm-Bodied Fishes
36 Citations1973Jeffrey B. Graham
The black skipjack, Euthynnus lineatus, uses a centrally located vascular heat exchanger to maintain core body temperatures warmer than ambient sea water to prevent the premature dissociation of oxygen from hemoglobin as blood is warmed en route to the muscles.
American Journal of Physiology-Endocrinology and MetabolismHeat production during contraction in skeletal muscle of hypothyroid mice
36 Citations1987W. J. Leijendekker, C. van Hardeveld +1 more
Journal of Experimental BiologyActivities of Key Metabolic Enzymes in the Heater Organs of Scombroid Fishes
36 Citations1991Alexa Tullis, Barbara A. Block +1 more
Results indicate that heat production could be fueled aerobically by either lipid or carbohydrate metabolism, and that fishes from the colder Mediterranean waters had a higher aerobic capacity and, hence, a greater heat-generating potential, than fish from the warmer waters of the Pacific.
Comparative Biochemistry and Physiology Part C Comparative PharmacologyEffect of acute temperature stress on the plasma catecholamine, corticosterone and metabolite levels in the pigeon
35 Citations1976Eila Jeronen, Paula Isometsä +2 more
It is shown that there are increased plasma glycerol, FFA, A and NA levels in cold-acclimated pigeon compared with heat-acClimated pigeon and an immediate fall at heat but a controversial elevation at cold was observed.
Canadian Journal of ZoologyCapillary–fiber geometrical relationships in tuna red muscle
33 Citations1992Odile Mathieu‐Costello, P.J. Agey +3 more
The size of the capillary–fiber interface at a given mitochondrial volume per fiber was not significantly different in tuna red muscle compared with rat soleus muscle, however, calculation of mitochondrial respiratory rates in tunared muscle yielded a substantially lower value.
Journal of Experimental ZoologyOxidative metabolism in thermogenic tissues of the swordfish and mako shark
31 Citations1992James S. Ballantyne, M. E. Chamberlin +1 more
It does not appear that mako shark red muscle mitochondria are specialized for thermogenesis, and it is proposed that calcium released from the sarcoplasmic reticulum may act as the signal coupling enhanced rates of substrate oxidation with calcium transport.
Cell CalciumEffects of the thyroid status on the sarcoplasmic reticulum in slow skeletal muscle of the rat
30 Citations1986Warner S. Simonides, Cornelis van Hardeveld
The results suggest that thyroid hormone stimulates the proliferation of the SR and possibly also increases the Ca++-pump density in the SR membrane.
Respiration PhysiologyAerobic activity estimated by exercise vs cold-exposure: Endurance training effects in rats
27 Citations1985Kevin E. Conley, Ewald R. Weibel +2 more
The thermogenically-based VO2max(cold) did not reflect the adaptation to endurance training shown by exercise-elicited VO2 max and cannot be used interchangeably as measures of aerobic capacity.
Biochimica et Biophysica Acta (BBA) - BioenergeticsDifferentiation of brown adipose tissue and biogenesis of thermogenic mitochondria in situ and in cell culture
26 Citations1990J Houštěk, Ján Kopecký +4 more
Both in situ and in cell culture, the conditions enabling the expression of UCP gene were accompanied by activation of intracellular thyroxine 5'-deiodinase, and UCP was quantitatively incorporated into mitochondria and within 24 h after stimulation reached near physiological concentration.
Journal of Fish BiologyA histochemical, light and electron microscopic examination of eel, <i>Anguilla rostrata</i> red and white muscle
26 Citations1978William C. Hulbert, Thomas W. Moon
It is suggested (1) the myofibrillar partitioning may reflect an altered functional role of red muscle and (2) eel white muscle may provide a portion of the muscular power required to sustain cruising speeds necessary for the long seaward migration of this animal.
Annual Review of PhysiologyEnergetics of Locomotion in Warm-Bodied Fish
25 Citations1982Doris Stevens, Andrew E. Dizon
This review focuses on a few species of tunas but draws on information from other fish (especially salmonids) to fill in the gaps in the authors' understanding.
Journal of Food ScienceBurnt Tuna: An Ultrastructural Study of Postmortem Changes in Muscle of Yellowfin Tuna ( <i>Thunnus albacares</i> ) Caught on Rod and Reel and Southern Bluefin Tuna ( <i>Thunnus maccoyii</i> ) Caught on Handline or Longline
24 Citations1986Peter S. Davie, R. I. Sparksman
Burnt tuna meat occurred in carcasses showing a greatly accelerated rate of postmortem degeneration, and longer capture times are correlated with better ultrastructural quality of tuna meat, and less burning.
Journal of Thermal BiologyAn ultrastructural and histological analysis of the effects of cold acclimation on vertebrate skeletal muscle
23 Citations1978James S. Ballantyne, John C. George
Cold acclimation resulted in decreased fibre size in several homeotherms with a concomitant increase in mitochondrial content and a relationship has been established between red fibre size and mitochondrial content for several species of homeotherm which suggests that with decreased muscle fibre size, mitochondrial content increases.
Experimental Biology and MedicineCalorigenesis of Brown Adipose Tissue in Cold-Exposed Rats
21 Citations1968Yusuke Imai, Barbara A. Horwitz +1 more
From the temperature changes observed when the rats were reexposed to cold, the heat produced by the interscapular pad was calculated and extrapolated to that of the total brown fat and indicated that during cold stress the intrinsic metabolism of brown adipose tissue accounted for 8.2% of thetotal heat production.
…