Pathogenesis of Congenital Rubella
JAMAPublished 20 December 1965
Richard L. Naeye
Citations198
SJR quartileQ1
SJR score5.35
SNIP10.71
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TL;DR
The subnormal number of cells in many body organs provides a partial explanation for the long-term physical and mental retardation encountered in some persons who have had congenital rubella.
Abstract
A quantitative study has been made of organ and cellular development in eight newborn and seven older infants with congenital rubella. The infants were subnormal in size at birth due to retarded intrauterine growth. A further retardation of growth was observed in the postnatal period. The basis of growth retardation in such infants is a subnormal number of cells in many body organs. The cause of the growth disturbance appears to be an activity of the proliferating virus which inhibits cell multiplication. Necrotic or inflammatory changes in the tissues are rare. The subnormal number of cells in many body organs provides a partial explanation for the long-term physical and mental retardation encountered in some persons who have had congenital rubella.
Keywords
MedicineBiochemistry, Genetics and Molecular Biology
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Two newborn infants are presented whose mothers had rubella in the first trimester of pregnancy, born with thrombocytopenic purpura and suggestive evidence of a hemolytic disorder and shown to be harboring an interfering agent with the characteristics of the rubella virus.
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16 Citations1962Rolf Lundström, S Ahnsjö
Children of mothers who had contracted rubella in early pregnancy in 1951–1952 showed a higher incidence of subnormal head circumference than did control children and showed a delayed functional development, as judged from the age at which they sat and/or stood by themselves.
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