The human apolipoprotein A-II gene is located on chromosome 1
Biochemical and Biophysical Research CommunicationsPublished 1 August 1984
Karl J. Lackner, S W Law, H Bryan Brewer, A.Y. Sakaguchi, Susan L. Naylor
Citations39
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SJR score0.75
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TL;DR
Apolipoprotein (apo) A-II is a major constituent of high density lipoproteins (HDL) and comparison with previously established gene loci on chromosomes 1 suggests that apoA-II may reside in a conserved linkage group with renin and peptidase C.
Abstract
Apolipoprotein (apo) A-II is a major constituent of high density lipoproteins (HDL). The gene for apoA-II has been localized to the p21----qter region of chromosome 1 in man by Southern blot hybridization analysis of DNA from human-mouse cell hybrids using a cloned human apoA-II cDNA probe. The regional assignment was established using two hybrids carrying a reciprocal translocation involving chromosomes 1 and 2. Comparison with previously established gene loci on chromosomes 1 suggests that apoA-II may reside in a conserved linkage group with renin and peptidase C. On the other hand, apoA-II is not linked to the apoA-I gene, which has been localized previously to chromosome 11.
Keywords
MedicineBiochemistry, Genetics and Molecular Biology
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