Fluorine substituent effects (on bioactivity)
Journal of Fluorine ChemistryPublished 1 June 2001
Bruce E. Smart
Citations1,450
SJR quartileQ3
SJR score0.33
SNIP0.57
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Abstract
The characteristic effects of fluorine and fluoroalkyl substituents on the physico-chemical properties of molecules that are important to biological activity of fluorinated compounds are highlighted. The influence of fluorination on acidity, hydrogen-bonding, and lipophilicity that affect compound absorption and distribution is described. The current perspectives on fluorine steric interactions and the controversial role of hydrogen-bonding involving the CF bond are discussed.
Keywords
ChemistryPharmacology, Toxicology and Pharmaceutics
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