ROLE OF ADRENERGIC RECEPTORS IN GLUCOSE-INDUCED INSULIN SECRETION IN MAN
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TL;DR
Results indicate that, in man, glucose-induced insulin release is mediated by adenyl cyclase and, consequently, by the intracellular level of cyclic adenosine monophosphate.
Abstract
Administration to healthy volunteers of a β-receptor blocker (propranolol) in most instances significantly inhibited the insulin response to glucose infusion, while α-receptor blocking (by phentolamine) enhanced the insulin release. The inhibition induced by the β-blocking agent was totally or partially overcome by simultaneous administration of aminophylline. These results indicate that, in man, glucose-induced insulin release is mediated by adenyl cyclase and, consequently, by the intracellular level of cyclic adenosine monophosphate.