Hospitalization for heart failure in the presence of a normal left ventricular ejection fraction
Journal of the American College of CardiologyPublished 1 April 2004
Marc Klapholz, Matthew Maurer, April M. Lowe, Frank C. Messineo, Jay S. Meisner, Judith E. Mitchell
Citations370
SJR quartileQ1
SJR score9.02
SNIP6.30
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TL;DR
Patients hospitalized for heart failure with a normal ejection fraction are most often chronically incapacitated elderly women with a history of hypertension and increased LV mass, and reasons for clinical decompensation are identified in only one-half of patients.
Abstract
Patients hospitalized for HFNEF are most often chronically incapacitated elderly women with a history of hypertension and increased LV mass. Reasons for clinical decompensation are identified in only one-half of patients.
Keywords
Medicine
Journal of the American Society of EchocardiographyRecommendations for Quantitation of the Left Ventricle by Two-Dimensional Echocardiography
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