Cholinergic and inhibitory synapses in a pathway from motor‐axon collaterals to motoneurones
The Journal of PhysiologyPublished 30 December 1954Open access
J. C. Eccles, P. Fatt, K. Koketsu
Citations1,186
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Keywords
Neuroscience
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It was suggested that observations support the conception of a chemical transmission of excitation from motor nerve to voluntary muscle, by the release of acetylcholine at the nerve endings, and a number of choline esters and other substances having a "nicotine-like" action were tested.
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An analysis has been made of the electrical responses recorded on the surface and within the substance of the first sacral spinal segment when the contained motoneurons are excited by single and repeated antidromic ventral root volleys, finding a succession of negative deflections, designated in order of increasing latency m, i, b, d, that represent impulse conduction through successive parts of the mot oneurons that differ in behavior.
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It is shown that the intrinsic recovery process of the motoneuron somata cannot be measured in the presence of current flow it must be estimated by correcting the observed recovery for the influence of known current flows, and the recovery cycle of ventral root axons in general compares with the after-potential cycle.
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The experiments to be described in this paper were the first step in some work which was begun in April 1935, after Dale & Feldberg had suggested that acetylcholine might be the chemical transmitter at motor nerve endings, and which has been partly summarized in previous notes.
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Any discussion on the problem of how to explain central excitation and inhibition by chemical transmission must, I think, at the present stage of the authors' knowledge be based mainly on transmission by acetylcholine at neuromuscular junctions and synapses in autonomic ganglia.