Effects of hypophysectomy and ACTH1–10 on responsiveness to electric shock in rats

Physiology & BehaviorPublished 1 February 1970Open access

Willem Hendrik Gispen, Tj. B. van Wimersma Greidanus, D. de Wied

Citations61

TL;DR

It is concluded that the stimulating effect of ACTH1–10 on conditioned avoidance acquisition in hypophysectomized rats is not caused by an influence on sensory capacities.

Abstract

Response behavior of rats to unescapable electric shock was studied in intact and hypophysectomized animals. The threshold for flinch, jerk, run and jump was significantly lowered in hypophysectomized rats as compared to that of intact controls. Treatment with the ACTH analogue ACTH1–10 did not affect threshold levels in hypophysectomized nor in intact rats. It is concluded that the stimulating effect of ACTH1–10 on conditioned avoidance acquisition in hypophysectomized rats is not caused by an influence on sensory capacities.

Keywords

MedicineNeuroscience

PsychopharmacologyA new technique for the investigation of some analgesic drugs on a reflexive behavior in the rat

261 Citations1961Wayne Ο. Evans

The analgetic action of a series of analgesic and psychotropic agents was tested in a situation in which variable intensities of electric shock to a rat's feet were used to elicit two distinguishable reflexive responses: a "flinching" response at low shock values and a “jumping” response at higher shock values.

Experimental Biology and MedicineInhibitory Effect of ACTH and Related Peptides on Extinction of Conditioned Avoidance Behavior in Rats

258 Citations1966D. de Wied

It appeared that ACTH and related peptides significantly delayed the rate of extinction of the avoidance response in rats, and results were interpreted to indicate that the active part of ACTH in this respect is located in the N-terminal part of the molecule.

ScienceLesions in the Medial Forebrain Bundle: Delayed Effects on Sensitivity to Electric Shock

71 Citations1965John A. Harvey, Carlton E. Lints

Rats with bilateral lesions in the medial forebrain bundle demonstrate both an increased sensitivity to electric shock, as reflected by a lowered jump threshold, and a decrease in the concentration of serotonin in the brain, which is suggested to be due to a central denervation supersensitivity.

Physiology & BehaviorDrug induced reversal of brain damage in the rat

71 Citations1969Carlton E. Lints, John A. Harvey

Lesions in the medial forebrain bundle of the rat produced both an increased sensitivity to electric-foot shock and a decrease in the telencephalic content of serotonin, and administration of dl -5-hydroxytryptophan reversed the effects of the lesion on shock sensitivity.

Experimental NeurologySensitivity to electric shock after ventromedial hypothalamic lesions

55 Citations1967Steven G. Turner, Jeri A. Sechzer +1 more

Bilateral ventromedial hypothalamic lesions were produced in mice with gold-thioglucose and in rats with electric current and animals with lesions showed markedly lower shock thresholds than the control subjects.

European Journal of EndocrinologyCORRELATED STUDIES ON PLASMA FREE CORTICOSTERONE AND ON ADRENAL STEROID FORMATION RATE IN VITRO

53 Citations1960van der Vies, R. F. M. Bakker +1 more

Animal BehaviourStrain differences in response to shock in rats selectively bred for emotional elimination

53 Citations1968John Wilcock

It was found that the MNR strain, which learns shuttle-box CARs more quickly than the MR strain, nevertheless performed more motor responses incompatible with efficient shuttle- box crossing than the Mr. MR.