Effects of sleep fragmentation in healthy men on energy expenditure, substrate oxidation, physical activity, and exhaustion measured over 48 h in a respiratory chamber
American Journal of Clinical NutritionPublished 28 July 2011Open access
Rick Hursel, Femke Rutters, Hanne K. J. Gonnissen, Eveline A Martens, Margriet S. Westerterp‐Plantenga
Citations92
SJR quartileQ1
SJR score2.11
SNIP1.75
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
Fragmented compared with nonfragmented sleep induced reductions in the most important sleep phases, which coincided with elevated AEE, physical activity, exhaustion, and sleepiness, which may predispose to overweight.
Abstract
Fragmented compared with nonfragmented sleep induced reductions in the most important sleep phases, which coincided with elevated AEE, physical activity, exhaustion, and sleepiness. RQ and carbohydrate oxidation increased and fat oxidation decreased, which may predispose to overweight. This trial is registered at www.who.int/ictrp and www.trialregister.nl as NTR1919.
Keywords
PsychologyMedicineNeuroscience
Journal of Psychosomatic ResearchThe three-factor eating questionnaire to measure dietary restraint, disinhibition and hunger
4,701 Citations1985Albert J. Stunkard, Samuel Messick
The first step was a collation of items from two existing questionnaires that measure the related concepts of 'restrained eating' and 'latent obesity', to which were added items newly written to elucidate these concepts.
The LancetImpact of sleep debt on metabolic and endocrine function
3,657 Citations1999Karine Spiegel, Rachel Leproult +1 more
Sleep debt has a harmful impact on carbohydrate metabolism and endocrine function similar to those seen in normal ageing and, therefore, sleep debt may increase the severity of age-related chronic disorders.
Annals of Internal MedicineBrief Communication: Sleep Curtailment in Healthy Young Men Is Associated with Decreased Leptin Levels, Elevated Ghrelin Levels, and Increased Hunger and Appetite
2,435 Citations2004Karine Spiegel, Esra Tasali +2 more
In this study, 12 young, healthy, normal-weight men exhibited reductions in the satiety hormone leptin, increases in the hunger hormone ghrelin, and increases in hunger after 2 nights of only 4 hours of sleep compared with after two nights of 10 hours ofSleep, suggesting inadequate sleep seems to influence the hormones that regulate satiety and hunger.
Proceedings of the National Academy of SciencesA Biometric Study of Human Basal Metabolism
1,955 Citations1918Jacqueline Harris, Fräncis G. Benedict
ObesityShort Sleep Duration and Weight Gain: A Systematic Review
1,509 Citations2008Sanjay R. Patel, Frank B. Hu
This work reviews the literature regarding short sleep duration as an independent risk factor for obesity and weight gain and suggests sleep deprivation may influence weight through effects on appetite, physical activity, and/or thermoregulation.
Sleep Medicine ReviewsThe metabolic consequences of sleep deprivation
1,335 Citations2007Kristen L. Knutson, Karine Spiegel +2 more
The present article reviews the current evidence in support of these three mechanisms that might link short sleep and increased obesity and diabetes risk.
The Journal of Clinical Endocrinology & MetabolismLeptin Levels Are Dependent on Sleep Duration: Relationships with Sympathovagal Balance, Carbohydrate Regulation, Cortisol, and Thyrotropin
1,001 Citations2004Karine Spiegel, Rachel Leproult +4 more
Sleep modulates a major component of the neuroendocrine control of appetite, and the effects of sleep duration on leptin were quantitatively associated with alterations of the cortisol and TSH profiles and were accompanied by an elevation of postbreakfast homeostasis model assessment values.
Proceedings of the National Academy of SciencesSlow-wave sleep and the risk of type 2 diabetes in humans
912 Citations2008Esra Tasali, Rachel Leproult +2 more
All-night selective suppression of slow-wave sleep results in marked decreases in insulin sensitivity without adequate compensatory increase in insulin release, leading to reduced glucose tolerance and increased diabetes risk, and the data suggest that reduced sleep quality with low levels of SWS may contribute to increase the risk of type 2 diabetes.
American Journal of Clinical NutritionSleep curtailment is accompanied by increased intake of calories from snacks
709 Citations2008Arlet Nedeltcheva, J. Kilkus +4 more
Recurrent bedtime restriction can modify the amount, composition, and distribution of human food intake, and sleeping short hours in an obesity-promoting environment may facilitate the excessive consumption of energy from snacks but not meals.
American Journal of Clinical NutritionTotal body water measurement in humans with 18O and 2H labeled water
667 Citations1980Dale A. Schoeller, E. van Santen +4 more
To determine if water labeled with the stable isotope 18O can yield faster and more accurate results, total body water was measured simultaneously using waterlabeled with both 18O and 2H and the H2(18)O dilutions were measured by mass spectrometry.
American Journal of EpidemiologyAssociation between Reduced Sleep and Weight Gain in Women
621 Citations2006Sanjay R. Patel, Atul Malhotra +3 more
CHEST JournalEffects of Sleep Fragmentation on Glucose Metabolism in Normal Subjects
599 Citations2009Katherine A. Stamatakis, Naresh M. Punjabi
Fragmentation of sleep across all stages is associated with a decrease in S(I) and S(G), and increases in sympathetic nervous system and adrenocortical activity likely mediate the adverse metabolic effects of poor sleep quality.
SLEEP24-Hour Metabolic Rate in Insomniacs and Matched Normal Sleepers
549 Citations1995Michael H. Bonnet, Donna L. Arand
It was concluded that patients who report chronic insomnia may suffer from a more general disorder of hyperarousal that may be responsible for both the daytime symptoms and the nocturnal poor sleep.
American Journal of Clinical NutritionAcute partial sleep deprivation increases food intake in healthy men
440 Citations2010Laurent Brondel, M. Romer +3 more
It is suggested that sleep restriction could be a factor that promotes obesity and, to a lesser extent, estimated physical activity-related energy expenditure in healthy men.
Sleep Medicine ReviewsIs sleep duration related to obesity? A critical review of the epidemiological evidence
418 Citations2008Nathaniel S. Marshall, Nick Glozier +1 more
It is argued that the evidence base is not yet strong enough to give public health advice to the general population or specific groups about sleep duration being a modifiable risk factor for obesity.
American Journal of Clinical NutritionShort-term sleep loss decreases physical activity under free-living conditions but does not increase food intake under time-deprived laboratory conditions in healthy men
399 Citations2009Sebastian Schmid, Manfred Hallschmid +6 more
Test the hypothesis that acute sleep loss decreases physical activity while increasing food intake, thereby shifting 2 crucial behavioral components of energy homeostasis toward weight gain, and short-term sleep loss neither increased food intake nor affected concentrations of the hunger-regulating hormones leptin and ghrelin.
Annals of Internal MedicineInsufficient Sleep Undermines Dietary Efforts to Reduce Adiposity
390 Citations2010Arlet Nedeltcheva, J. Kilkus +3 more
The amount of human sleep contributes to the maintenance of fat-free body mass at times of decreased energy intake and Lack of sufficient sleep may compromise the efficacy of typical dietary interventions for weight loss and related metabolic risk reduction.
Hormone Research in PaediatricsImpact of Sleep and Sleep Loss on Neuroendocrine and Metabolic Function
352 Citations2007Eve Van Cauter, Ulf Holmbäck +8 more
The Journal of Clinical Endocrinology & MetabolismExposure to Recurrent Sleep Restriction in the Setting of High Caloric Intake and Physical Inactivity Results in Increased Insulin Resistance and Reduced Glucose Tolerance
325 Citations2009Arlet Nedeltcheva, L. Kessler +2 more
Experimental bedtime restriction, designed to approximate the short sleep times experienced by many individuals in Westernized societies, may facilitate the development of insulin resistance and reduced glucose tolerance.
The Journal of PhysiologyEnergy expenditure during sleep, sleep deprivation and sleep following sleep deprivation in adult humans
316 Citations2010Christopher Jung, Edward L. Melanson +4 more
The finding that sleep deprivation increases energy expenditure should not be interpreted thatSleep deprivation is a safe or effective strategy for weight loss as other studies have shown that chronic sleep deprivation is associated with impaired cognition and weight gain.
International Journal of ObesityThe association between sleep duration and obesity in older adults
283 Citations2008Sanjay R. Patel, Terri Blackwell +10 more
In older men and women, actigraphy-ascertained reduced sleep durations are strongly associated with greater adiposity, after adjusting for sleep apnea, insomnia and daytime sleepiness.
International Journal of ObesityPhysical activity energy expenditure has not declined since the 1980s and matches energy expenditures of wild mammals
268 Citations2008K R Westerterp, John R. Speakman
As physical activity expenditure has not declined over the same period that obesity rates have increased dramatically, and daily energy expenditure of modern man is in line with energy expenditure in wild mammals, it is unlikely that decreased expenditure has fuelled the obesity epidemic.
Journal of Applied PhysiologyA dual-respiration chamber system with automated calibration
250 Citations1997Paul F.M. Schoffelen, Klaas R. Westerterp +2 more
It is concluded that response time is not the main factor with respect to the smallest practical measurement interval (duration); volume, mixing, gas-analysis accuracy, and levels of O2 consumption and CO2 production are at least equally important.
American Journal of Clinical NutritionAcute sleep deprivation reduces energy expenditure in healthy men
239 Citations2011Christian Benedict, Manfred Hallschmid +6 more
The findings show that one night of sleep deprivation acutely reduces energy expenditure in healthy men, which suggests that sleep contributes to the acute regulation of daytime energy expenditures in humans.
DiabetologiaAssociation of sleep duration with type 2 diabetes and impaired glucose tolerance
230 Citations2007Jean‐Philippe Chaput, Jean‐Philippe Després +2 more
Evidence is provided that short- and long-duration sleep times are associated with type 2 diabetes/IGT in adults, even after adjustment for several confounders.
Obesity FactsInfluence of Partial Sleep Deprivation on Energy Balance and Insulin Sensitivity in Healthy Women
214 Citations2008Anja Bosy‐Westphal, Silvia Hinrichs +8 more
Short-term sleep deprivation increased energy intake and led to a net weight gain in women and the effect of sleep restriction on energy expenditure needs to be specifically addressed in future studies using reference methods for total energy expenditure.
Sleep MedicineSleep duration as a risk factor for the development of type 2 diabetes or impaired glucose tolerance: Analyses of the Quebec Family Study
208 Citations2009Jean‐Philippe Chaput, Jean‐Pierre Després +3 more
Short and long sleeping times are associated with a higher risk of developing type 2 diabetes/IGT, independent of several covariates, and results suggest that sleep duration may represent a novel risk factor for type 2abetes/IGt.
Journal of Clinical InvestigationDiminished brain glucose metabolism is a significant determinant for falling rates of systemic glucose utilization during sleep in normal humans.
201 Citations1994P J Boyle, James C. Scott +4 more
A decline in brain glucose metabolism is a significant determinant of falling rates of systemic glucose utilization during sleep, and was more closely linked to duration of sleep.
American Journal of Clinical NutritionGluconeogenesis and energy expenditure after a high-protein, carbohydrate-free diet
169 Citations2009M. Veldhorst, Margriet S. Westerterp‐Plantenga +1 more
Forty-two percent of the increase in energy expenditure after the H diet was explained by the rise in gluconeogenesis, which is higher than in the N condition.
ScienceOxygen Consumption Rate and Electroencephalographic Stage of Sleep
163 Citations1965D. Robert Brebbia, Kenneth Z. Altshuler
In five male subjects, and a total of 15 man-nights, oxygen consumption rate (V02) was related to stage of sleep, as defined by electroencephalograms, with V02 highest in stage I REM (dreaming sleep), least in stages III and IV (deep sleep), and intermediate in stage II (light sleep).
Obesity ReviewsReduced sleep as an obesity risk factor
162 Citations2009Sanjay R. Patel
Reduced sleep appears to represent a novel, independent risk factor for increased weight gain.
Journal of Applied PhysiologyMetabolism during normal, fragmented, and recovery sleep
150 Citations1991Michael H. Bonnet, Richard B. Berry +1 more
Average metabolic data were obtained for each 3-min period during consecutive nights of normal, experimentally fragmented, and recovery sleep in a group of 12 normal young adult males to infer that increased metabolism during sleep causes nonrestorative sleep.
Sleep Medicine ClinicsImpact of Sleep and Sleep Loss on Glucose Homeostasis and Appetite Regulation
129 Citations2007Kristen L. Knutson
British Journal Of NutritionDeuterium dilution as a method for determining total body water: effect of test protocol and sampling time
129 Citations1994Wouter D. van Marken Lichtenbelt, Klaas R. Westerterp +1 more
It is concluded that 10h equilibration is preferable to the shorter 4h and 6h, for the determination of TBW.
MetabolismMetabolic rate and fuel utilization during sleep assessed by whole-body indirect calorimetry
94 Citations2009Yasuko Katayose, Mami Tasaki +4 more
The increases in energy expenditure and carbohydrate oxidation during REM sleep are consistent with a notion that changes in energy metabolism in brain are manifested as small fluctuations in whole-body energy metabolism during sleep.
American Journal of Physiology-Endocrinology and MetabolismRelationship between sleep stages and metabolic rate in humans
87 Citations1994A M Fontvieille, Russell Rising +3 more
It is suggested that sleep stages play a minor role in the variance of SMR among subjects, however, the duration of sleep may contribute to the variability of 24-h energy expenditure.
American Journal of Clinical NutritionComparison of 2 diets with either 25% or 10% of energy as casein on energy expenditure, substrate balance, and appetite profile
67 Citations2009Ananda Hochstenbach‐Waelen, M. Veldhorst +3 more
A 25En% casein diet boosts energy expenditure, protein balance, satiety, and negative fat balance, which is beneficial to body weight management, whereas positive carbohydrate balances were not significantly different between diets.
Current Opinion in Endocrinology Diabetes and ObesitySleep deprivation and energy metabolism: to sleep, perchance to eat?
64 Citations2007Plamen D. Penev
Evolution in an environment with limited resources has established bidirectional links between sleep and energy homeostasis, the molecular mechanisms of which are emerging rapidly.
Sleep Medicine ReviewsReply to Taheri and Thomas: Is sleep duration associated with obesity—U cannot be serious
7 Citations2008Nathaniel S. Marshall, Nick Glozier +1 more
Their sense of perplexity at Taheri and Thomas’ response was heightened by their attempt to equate the suggestion that the authors need better data on the putative obesity–sleep link with the scepticism faced by Doll and Bradford Hill as they looked at this subject.