Blood cholesterol and vascular mortality by age, sex, and blood pressure: a meta-analysis of individual data from 61 prospective studies with 55 000 vascular deaths
The LancetPublished 1 December 2007
Sarah Lewington, Gary Whitlock, Robert Clarke, Paul Sherliker, Jonathan Emberson, Jim Halsey
Citations2,307
SJR quartileQ1
SJR score12.11
SNIP22.72
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TL;DR
There is conclusive evidence from randomised trials that statins substantially reduce not only coronary event rates but also total stroke rates in patients with a wide range of ages and blood pressures.
Abstract
Total cholesterol was positively associated with IHD mortality in both middle and old age and at all blood pressure levels. The absence of an independent positive association of cholesterol with stroke mortality, especially at older ages or higher blood pressures, is unexplained, and invites further research. Nevertheless, there is conclusive evidence from randomised trials that statins substantially reduce not only coronary event rates but also total stroke rates in patients with a wide range of ages and blood pressures.
Keywords
Medicine
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