Enantioselective behavioral effects of threo-methylphenidate in rats
Pharmacology Biochemistry and BehaviorPublished 1 December 1991
David A. Eckerman, Sheryl S. Moy, Ann N. Perkins, Kennerly S. Patrick, George R. Breese
Citations25
SJR quartileQ1
SJR score0.95
SNIP0.81
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TL;DR
Temporal control of responding was reduced (FI) choice responding was equalized for most rats (Conc VI VI), and milk consumption was suppressed by d- MPH and dl-MPH.
Abstract
The relative potency of d- and l-threo-methylphenidate (d-MPH and l-MPH) was evaluated using three behavioral paradigms for rats: Responding maintained by a fixed-interval schedule of reinforcement (FI), responding maintained by a concurrent variable-interval schedule of reinforcement (Conc VI VI), and consumption of sweetened condensed milk during a 15-min free-access period. In each case the potency of the d-MPH enantiomer greatly exceeded that of the l-MPH enantiomer. Temporal control of responding was reduced (FI) choice responding was equalized for most rats (Conc VI VI), and milk consumption was suppressed by d-MPH and dl-MPH.
Keywords
PsychologyMedicineNeuroscience
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