Ductal carcinoma in situ of the breast. Heterogeneity of individual lesions
CancerPublished 1 January 1994Open access
Wayne J. Lennington, Roy A. Jensen, Leslie W. Dalton, David L. Page
Citations177
SJR quartileQ1
SJR score2.95
SNIP1.90
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TL;DR
Differences in pattern have become clinically significant as predictive indicators of success for planned local excisions of small DCIS lesions in patients with ductal carcinoma in situ.
Abstract
Different patterns of DCIS are frequently present within individual lesions (46 of 100), and the more advanced features of architectural atypia are regularly present centrally. This strongly supports the hypothesis that these lesions develop from a central focus and expand peripherally. Also, those lesions with low-grade DCIS at the periphery may be as amenable to local excision for cure as purely low-grade lesions.
Keywords
MedicineBiochemistry, Genetics and Molecular Biology
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