Basic Concepts and Methods for Joint Models of Longitudinal and Survival Data
Journal of Clinical OncologyPublished 4 May 2010Open access
Joseph G. Ibrahim, Haitao Chu, Liddy M. Chen
Citations464
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TL;DR
An introductory overview on joint modeling for longitudinal and survival data is given and a general discussion of a broad range of issues that arise in the design and analysis of clinical trials using joint models are presented.
Abstract
Joint models for longitudinal and survival data are particularly relevant to many cancer clinical trials and observational studies in which longitudinal biomarkers (eg, circulating tumor cells, immune response to a vaccine, and quality-of-life measurements) may be highly associated with time to event, such as relapse-free survival or overall survival. In this article, we give an introductory overview on joint modeling and present a general discussion of a broad range of issues that arise in the design and analysis of clinical trials using joint models. To demonstrate our points throughout, we present an analysis from the Eastern Cooperative Oncology Group trial E1193, as well as examine some operating characteristics of joint models through simulation studies.
Keywords
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