The many HATs of transcription coactivators
Trends in Biochemical SciencesPublished 1 January 2000
Christine E. Brown, Theresa Lechner, Laura L. S. Howe, Jerry L. Workman
Citations342
SJR quartileQ1
SJR score4.16
SNIP2.34
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TL;DR
The demonstration that HAT complexes interact with sequence-specific activator proteins illustrates how these complexes target specific genes.
Abstract
Histone acetylation is closely linked to gene transcription. The identification of histone acetyltransferases (HATs) and the large multiprotein complexes in which they reside has yielded important insights into how these enzymes regulate transcription. The demonstration that HAT complexes interact with sequence-specific activator proteins illustrates how these complexes target specific genes. In addition to histones, some HATs can acetylate non-histone proteins suggesting multiple roles for these enzymes.
Keywords
Biochemistry, Genetics and Molecular Biology
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