Mediterranean Dietary Pattern in a Randomized Trial
Archives of Internal MedicinePublished 8 June 1998
Michel de Lorgeril, Patricia Salen, Jean‐Louis Martin, Isabelle Monjaud, Philippe Boucher, Nicolle Mamelle
Citations363
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
This randomized trial suggests that patients following a cardioprotective Mediterranean-type diet have a prolonged survival and may also be protected against cancer.
Abstract
This randomized trial suggests that patients following a cardioprotective Mediterranean diet have a prolonged survival and may also be protected against cancer. Further studies are warranted to confirm the data and to explore the role of the different lipids and fatty acids in this protection.
Keywords
MedicineBiochemistry, Genetics and Molecular Biology
New England Journal of MedicineThe Effect of Pravastatin on Coronary Events after Myocardial Infarction in Patients with Average Cholesterol Levels
7,491 Citations1996Frank M. Sacks, Marc A. Pfeffer +10 more
It is demonstrated that the benefit of cholesterol-lowering therapy extends to the majority of patients with coronary disease who have average cholesterol levels and was also greater in patients with higher pretreatment levels of LDL cholesterol.
New England Journal of MedicineThe Effect of Vitamin E and Beta Carotene on the Incidence of Lung Cancer and Other Cancers in Male Smokers
4,695 Citations1994The Alpha-Tocopherol Beta Carotene Cancer Prevention Study Group
No reduction in the incidence of lung cancer among male smokers is found after five to eight years of dietary supplementation with alpha-tocopherol or beta carotene, and this trial raises the possibility that these supplements may actually have harmful as well as beneficial effects.
New England Journal of MedicineEffects of a Combination of Beta Carotene and Vitamin A on Lung Cancer and Cardiovascular Disease
3,639 Citations1996Gilbert S. Omenn, Gary E. Goodman +10 more
After an average of four years of supplementation, the combination of beta carotene and vitamin A had no benefit and may have had an adverse effect on the incidence of lung cancer and on the risk of death from lung cancer, cardiovascular disease, and any cause in smokers and workers exposed to asbestos.
Nutrition and CancerFruit, vegetables, and cancer prevention: A review of the epidemiological evidence
3,250 Citations1992Gladys Block, Blossom H. Patterson +1 more
It would appear that major public health benefits could be achieved by substantially increasing consumption of fruit and vegetable consumption, and in particular in cancers of the esophagus, oral cavity, and larynx, for which 28 of 29 studies were significant.
Journal of Clinical InvestigationRole of oxidized low density lipoprotein in atherogenesis.
2,675 Citations1991Joseph L. Witztum, Daniel Steinberg
These ideas suggest new approaches, that in combination with lowering of plasma cholesterol, could lead to the prevention of atherosclerosis and its complications.
New England Journal of MedicineLack of Effect of Long-Term Supplementation with Beta Carotene on the Incidence of Malignant Neoplasms and Cardiovascular Disease
2,409 Citations1996Charles H. Hennekens, Julie E. Buring +10 more
In this trial among healthy men, 12 years of supplementation with beta carotene produced neither benefit nor harm in terms of the incidence of malignant neoplasms, cardiovascular disease, or death from all causes.
The LancetMediterranean alpha-linolenic acid-rich diet in secondary prevention of coronary heart disease
2,134 Citations1994M. de Lorgeril, S. Renaud +7 more
An alpha-linolenic acid-rich Mediterranean diet seems to be more efficient than presently used diets in the secondary prevention of coronary events and death.
New England Journal of MedicineA Clinical Trial of Antioxidant Vitamins to Prevent Colorectal Adenoma
766 Citations1994E. Robert Greenberg, John A. Baron +15 more
The lack of efficacy of these vitamins argues against the use of supplemental beta carotene and vitamins C and E to prevent colorectal cancer.
Annual Review of NutritionDietary Carotenes, Vitamin C, and Vitamin E as Protective Antioxidants in Human Cancers
524 Citations1992T. Byers, Guy M. L. Perry
Information is provided on how to identify the phytochemical properties of E.coli, which can be helpful in the preparation of food for human consumption and for animal welfare purposes.
New England Journal of MedicinePheochromocytomas, Multiple Endocrine Neoplasia Type 2, and von Hippel-Lindau Disease
471 Citations1993Hartmut P.H. Neumann, Dietmar Berger +6 more
All patients with pheochromocytomas should be screened for MEN-2 and von Hippel-Lindau disease to avert further morbidity and mortality in the patients and their families.
Proceedings of the National Academy of SciencesLow density lipoprotein rich in oleic acid is protected against oxidative modification: implications for dietary prevention of atherosclerosis.
462 Citations1990S Parthasarathy, John C. Khoo +4 more
The results suggest that diets sufficiently enriched in oleic acid, in addition to their LDL-lowering effect, may slow the progression of atherosclerosis by generating LDL that is highly resistant to oxidative modification.
Journal of Clinical InvestigationImmunologic effects of national cholesterol education panel step-2 diets with and without fish-derived N-3 fatty acid enrichment.
358 Citations1993S N Meydani, Alice H. Lichtenstein +6 more
American Journal of Clinical NutritionCretan Mediterranean diet for prevention of coronary heart disease
340 Citations1995S. Renaud, M. de Lorgeril +8 more
A Cretan Mediterranean diet adapted to a Western population protected against coronary heart disease much more efficiently than did the prudent diet, and it appears that the favorable life expectancy of the Cretans could be largely due to their diet.
JNCI Journal of the National Cancer InstituteRandomized Trial of Intake of Fat, Fiber, and Beta Carotene to Prevent Colorectal Adenomas
334 Citations1995Robert MacLennan, Finlay Macrae +11 more
The finding that the combination of fat reduction and a supplement of wheat bran reduced the incidence of large adenomas in this randomized, controlled trial must be treated with caution.
American Journal of Clinical NutritionFeasibility of using an oleate-rich diet to reduce the susceptibility of low-density lipoprotein to oxidative modification in humans
317 Citations1991Peter D. Reaven, Sampath Parthasarathy +7 more
The feasibility of altering the diet in a way that will not raise LDL cholesterol concentrations and yet will decrease the susceptibility of LDL to oxidative modification is demonstrated.
Journal of the American College of CardiologyEffect of a mediterranean type of diet on the rate of cardiovascular complications in patients with coronary artery disease insights into the cardioprotective effect of certain nutriments
230 Citations1996Michel de Lorgeril, Patricia Salen +5 more
The hypothesis is that different pathogenetic mechanisms were responsible for the development of the various complications in the Lyon Diet Heart Study and it is likely that certain nutriments characteristic of the Mediterranean diet have specific cardioprotective effects.
Breast Cancer Research and TreatmentInfluence of n-3 fatty acids on the growth of human breast cancer cellsin vitro: Relationship to peroxides and Vitamin-E
196 Citations1995V�ronique Chaj�s, Wolfgang Sattler +2 more
PUFA's significantly interfere with cell proliferation of breast cancer cells in vitro due to the formation of oxidation products, indicating that there must be other factors involved in the differential metabolism of PUFA's in tumor cells.
The FASEB JournalDietary n‐3 (ω‐3) polyunsaturated fatty acid effects on animal tumorigenesis
184 Citations1991William T. Cave
Results of numerous animal models affirm the importance of qualitative, as well as quantitative, dietary lipid differences on tumorigenesis, and strengthens the probability that further advances in understanding of lipid‐tumor interrelationships will have important preventive and therapeutic medical benefits.
BloodDietary omega-3 fatty acids lower levels of platelet-derived growth factor mRNA in human mononuclear cells
134 Citations1993WE Kaminski, Ellen Jendraschak +2 more
American Journal of Clinical NutritionFruit and vegetable consumption and cancer risk in a Mediterranean population
110 Citations1995Alessandra Tavani, Carlo La Vecchia
Ecological, case-control, and cohort studies present convincing evidence that diets rich in fresh fruit and vegetables protect against several common epithelial neoplasms, as well as for other epithelial cancers.
New England Journal of MedicineAspirin as Prophylaxis against Colorectal Cancer
81 Citations1995Aaron J. Marcus
An analysis of the incidence of colorectal cancer among women participating in the Nurses' Health Study according to whether they did or did not use aspirin on a regular basis showed a statistically significant reduction among women who took four to six aspirin tablets per week for more than 10 years.
PubMedDietary fiber-mediated mechanisms in carcinogenesis.
65 Citations1992David M. Klurfeld
Two hypotheses do not adequately explain modulation of tumor growth by dietary fiber: short-chain fatty acids and readily fermentable fibers such as guar and pectin would be more protective than cellulose and wheat bran.
European Journal of Clinical NutritionControl of bias in dietary trial to prevent coronary recurrences: The Lyon diet heart study
60 Citations1997M. de Lorgeril, Patricia Salen +4 more
Evidence is provided that the dietary modifications per se were protective, not other (including psychosocial) changes resulting from the participation to the trial, although the study cannot be completely shielded from minor biases.
