Treatment of Osteoarthritis With Celecoxib, a Cyclooxygenase-2 Inhibitor: A Randomized Controlled Trial
Mayo Clinic ProceedingsPublished 1 November 1999
W. Bensen, Justus J. Fiechtner, James I. McMillen, William W. Zhao, Shawn Yu, Emmett M. Woods
Citations350
SJR quartileQ1
SJR score2.00
SNIP2.28
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
COX-2 inhibition with celecoxib is an effective approach for the treatment of osteoarthritis, as seen by clinical improvement in signs and symptoms comparable to treatment with naproxen.
Abstract
COX-2 inhibition with celecoxib is an effective approach for the treatment of osteoarthritis, as seen by clinical improvement in signs and symptoms comparable to treatment with naproxen.
Keywords
ChemistryMedicineNeuroscience
PubMedValidation study of WOMAC: a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee.
7,818 Citations1988Nicholas Bellamy, W. Watson Buchanan +3 more
WOMAC is a disease-specific purpose built high performance instrument for evaluative research in osteoarthritis clinical trials and fulfil conventional criteria for face, content and construct validity, reliability, responsiveness and relative efficiency.
Arthritis & RheumatismDevelopment of criteria for the classification and reporting of osteoarthritis: Classification of osteoarthritis of the knee
6,777 Citations1986Roy D. Altman, E. Asch +23 more
Variables from the medical history, physical examination, laboratory tests, and radiographs were used to develop sets of criteria that serve different investigative purposes and these proposed criteria utilize classification trees, or algorithms.
BiometrikaA sharper Bonferroni procedure for multiple tests of significance
4,677 Citations1988Yosef Hochberg
JAMATHERAPEUTIC CRITERIA IN RHEUMATOID ARTHRITIS
2,883 Citations1949Otto Steinbrocker
This report summarizes recommendations for uniform therapeutic criteria in rheumatoid arthritis and highlights the varied language used in the body and conclusions of articles on therapy which did not lend themselves to any accurate appraisal.
Journal of Medicinal ChemistrySynthesis and Biological Evaluation of the 1,5-Diarylpyrazole Class of Cyclooxygenase-2 Inhibitors: Identification of 4-[5-(4-Methylphenyl)-3- (trifluoromethyl)-1<i>H</i>-pyrazol-1-yl]benzenesulfonamide (SC-58635, Celecoxib)
1,960 Citations1997Thomas D. Penning, John J. Talley +21 more
1i (4-[5-(4-methylphenyl)-3-(trifluoromethyl)- H-pyrazol-1-yl]benzenesulfonamide, SC-58635, celecoxib), which is currently in phase III clinical trials for the treatment of rheumatoid arthritis and osteoarthritis, is identified.
Proceedings of the National Academy of SciencesExpression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing.
1,716 Citations1991Wei Xie, Jeffrey G. Chipman +3 more
A distinguishing feature of src-inducible prostaglandin synthase mRNA is its low abundance in nonproliferating chicken embryo fibroblasts and its relatively high abundance in src-transformed cells.
PainDevelopment of the Wisconsin Brief Pain Questionnaire to assess pain in cancer and other diseases
1,570 Citations1983Randall L. Daut, Charles S. Cleeland +1 more
The development of a self‐report instrument designed to assess pain in cancer and other diseases and the evaluated Wisconsin Brief Pain Questionnaire suggest that the BPQ is sufficiently reliable and valid for research purposes.
Proceedings of the National Academy of SciencesPharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain.
1,562 Citations1994Karen Seibert, Y Zhang +6 more
In an animal model of acute inflammation, a selective inhibitor of COX-2 inhibited edema at the inflammatory site and was analgesic but had no effect on PG production in the stomach and did not cause gastric toxicity.
Proceedings of the National Academy of SciencesSelective inhibition of inducible cyclooxygenase 2 in vivo is antiinflammatory and nonulcerogenic.
1,315 Citations1994Jaime L. Masferrer, Ben S. Zweifel +6 more
Results suggest that inhibitors of COX-2 are potent antiinflammatory agents which do not produce the typical side effects associated with the nonselective,COX-1-directed antiinflammatory drugs.
Annals of Internal MedicineMisoprostol Reduces Serious Gastrointestinal Complications in Patients with Rheumatoid Arthritis Receiving Nonsteroidal Anti-Inflammatory Drugs
1,060 Citations1995Fred E. Silverstein, David Y. Graham +5 more
This objective was to determine whether concurrent therapy with misoprostol reduces the incidence of serious upper gastrointestinal complications in older patients with chronic rheumatoid arthritis who are taking NSAIDs.
Arthritis & RheumatismGuidelines for the medical management of osteoarthritis
973 Citations1995Marc C. Hochberg, Roy D. Altman +6 more
Patients with severe symptomatic OA of the hip require an aggressive approach to decreasing pain, increasing mobility, and improving function; such patients may benefit from orthopedic consultation and evaluation for osteotomy or total joint arthroplasty.
Journal of Biological ChemistryThe induction and suppression of prostaglandin H2 synthase (cyclooxygenase) in human monocytes.
943 Citations1990Jianmin Fu, Jaime L. Masferrer +3 more
Immunoprecipitation of [35S]methionine-labeled cyclooxygenase confirmed that the effect of lipopolysaccharide and dexamethasone on the monocyte prostanoid production could be attributed to an increase or decrease, respectively, in cellular cyclo oxygengenase de novo synthesis.
JAMAAnti-inflammatory and Upper Gastrointestinal Effects of Celecoxib in Rheumatoid Arthritis
804 Citations1999Lee S. Simon, Arthur L. Weaver +9 more
All dosages of celecoxib were efficacious in the treatment of rheumatoid arthritis and did not affect COX-1 activity in the GI tract mucosa as evidenced by less frequent incidence of endoscopic ulcers compared with naproxen.
JAMAQuality Improvement Guidelines for the Treatment of Acute Pain and Cancer Pain
802 Citations1995Mitchell B. Max
Quality improvement programs to improve treatment of acute pain and cancer pain should include five key elements, ensuring that a report of unrelieved pain raises a "red flag" that attracts clinicians' attention, and improved coordination of the process of assessing and treating pain.
Scandinavian Journal of RheumatologyIndexes of Severity for Osteoarthritis of the Hip and Knee:<i>Validation–Value in Comparison with Other Assessment Tests</i>
775 Citations1987M Lequesne, C Méry +2 more
The index for hip disease was established, validated and appraised as a new assessment test for the trial of new drugs as well as for long-term follow-up of patients, and to help with future indications for surgery.
Advances in immunologyProstaglandin Endoperoxide H Synthases-1 and -2
718 Citations1996William L. Smith, David L. DeWitt
The chapter compares and contrasts the structural and kinetic properties of prostaglandin endoperoxide H synthase-1 (PGHS-1) and -2 and discusses the description of the interactions of the two isozymes with nonsteroidal anti-inflammatory drugs (NSAIDs).
FEBS LettersExpression of mRNA for cyclooxygenase‐1 and cyclooxygenase‐2 in human tissues
711 Citations1993Gary P. O’Neill, Anthony W. Ford‐Hutchinson
PubMedCOX-1 and COX-2 tissue expression: implications and predictions.
680 Citations1997Crofford Lj
It has been proposed that cyclooxygenase (COX)-1 and COX-2 subserve different physiologic functions largely because of the striking differences in their tissue expression and regulation, and it is predicted that highly selective inhibitors of COx-2 will provide effective antiinflammatory activity with marked reduction in toxicity.
Journal of Clinical InvestigationCyclooxygenase-1 and -2 expression in rheumatoid synovial tissues. Effects of interleukin-1 beta, phorbol ester, and corticosteroids.
658 Citations1994Leslie J. Crofford, R L Wilder +5 more
Modulation of Cox-2 expression by IL-1 beta and corticosteroids may be an important component of the inflammatory process in synovial tissues from patients with RA.
New England Journal of MedicineComparison of an Antiinflammatory Dose of Ibuprofen, an Analgesic Dose of Ibuprofen, and Acetaminophen in the Treatment of Patients with Osteoarthritis of the Knee
627 Citations1991John Bradley, Kenneth D. Brandt +3 more
In short-term, symptomatic treatment of osteoarthritis of the knee, the efficacy of acetaminophen was similar to that of ibuprofen, whether the latter was administered in an analgesic or an antiinflammatory dose.
Journal of Clinical InvestigationSelective inhibition of cyclooxygenase (COX)-2 reverses inflammation and expression of COX-2 and interleukin 6 in rat adjuvant arthritis.
571 Citations1996Graham Anderson, Scott D. Hauser +4 more
It is suggested that COX-2 plays a prominent role in the inflammation associated with adjuvant arthritis and that COx-2 derived PGs upregulate CO X-2 and IL-6 expression at inflammatory sites.
The LancetCelecoxib versus diclofenac in long-term management of rheumatoid arthritis: randomised double-blind comparison
539 Citations1999Paul Emery, H. Zeidler +8 more
Celecoxib showed sustained anti-inflammatory and analgesic activity similar to diclofenac, with a lower frequency of upper gastrointestinal ulceration or gastrointestinal adverse events, and tolerability was better.
Arthritis & RheumatismPreliminary study of the safety and efficacy of SC-58635, a novel cyclooxygenase 2 inhibitor: Efficacy and safety in two placebo-controlled trials in osteoarthritis and rheumatoid arthritis, and studies of gastrointestinal and platelet effects
476 Citations1998Lee S. Simon, Frank L. Lanza +6 more
SC-58635 achieves analgesic and antiinflammatory efficacy in arthritis through selectiveCOX-2 inhibition, without showing any evidence of 2 of the toxic effects of COX-1 inhibition associated with nonsteroidal antiinflammatory drugs.
Journal of Pharmacology and Experimental TherapeuticsDifferential inhibition of human prostaglandin endoperoxide H synthases-1 and -2 by nonsteroidal anti-inflammatory drugs.
472 Citations1994Odette Laneuville, D.K. Breuer +4 more
An in vitro expression system for accurate kinetic analyses of the inhibition of the human prostaglandin H synthase isozymes by nonsteroidal anti-inflammatory drugs (NSAIDs) indicates that neither measurements of affinities of NSAIDs for hPGHS-2 conducted in vitro with 10 microM arachidonate nor measurements of time-dependent inhibition of hPG HS-2 always predict whether a compound has anti- inflammatory activity in vivo.
GastroenterologyCharacterization of Prostaglandin G/H Synthase 1 and 2 in rat, dog, monkey, and human gastrointestinal tracts
465 Citations1996Stacia Kargman, S. Charleson +6 more
Results indicate that prostaglandins produced in normal gastrointestinal tissue and required for normal physiological functioning are derived from the PGHS-1 isoform.
Biochemical JournalExpression and selective inhibition of the constitutive and inducible forms of human cyclo-oxygenase
417 Citations1995James K. Gierse, Scott D. Hauser +5 more
The results demonstrate the ability to generate selective non-steroidal anti-inflammatory drugs (NSAIDs), which could provide useful improvement therapeutically in the treatment of chronic inflammatory disease.
Journal of Biological ChemistryDexamethasone inhibits mitogen induction of the TIS10 prostaglandin synthase/cyclooxygenase gene.
406 Citations1992Dean A. Kujubu, Harvey R. Herschman
Inhibition of the synthesis of TIS10 prostaglandin synthase/cyclooxygenase may be a principal mechanism by which glucocorticoids block prostaglandsin synthesis and secretion.
Journal of Clinical InvestigationSuperinduction of cyclooxygenase-2 activity in human osteoarthritis-affected cartilage. Influence of nitric oxide.
386 Citations1997Ashok R. Amin, Mukundan Attur +7 more
The data indicate that human OA-affected cartilage in ex vivo conditions shows superinduction of PGE2 due to upregulation of COX-2, and spontaneous release of NO that acts as an autacoid to attenuate the production of the COx-2 products such as P GE2.
Journal of Clinical InvestigationRegulation of eicosanoid production and mitogenesis in rat intestinal epithelial cells by transforming growth factor-alpha and phorbol ester.
372 Citations1994Raymond N. DuBois, Joseph Awad +3 more
A mitogen-inducible cyclooxygenase gene is shown to be regulated by TGF alpha and TPA in rat intestinal epithelial cells and it is suggested that products of an intestinal growth factor-inducing cyclo oxygengenase may play a role in the regulation of mitogenesis.
Arthritis & RheumatismA Seven‐Day variability study of 499 patients with peripheral rheumatoid arthritis
241 Citations1965Donald Mainland
At eleven clinics uniform methods of measuring disease activity produced two sets of tables: interpatient single-examination differences (499 patients); changes in one week (411 patients with unchanged therapy); and a method of correcting for initial disease severity in controlled trials.
Journal of Pharmacology and Experimental TherapeuticsInhibition of Cyclooxygenase-2 Rapidly Reverses Inflammatory Hyperalgesia and Prostaglandin E2 Production
231 Citations1997Yan Zhang, Alex Shaffer +3 more
It is suggested that continuous production of PGE2 by the COX-2 enzyme is a critical element in sustaining the hyperalgesic response at sites of tissue inflammation.
Arthritis & RheumatismExpression of cyclooxygenase 1 and cyclooxygenase 2 in human synovial tissue: Differential elevation of cyclooxygenase 2 in inflammatory joint diseases
214 Citations1998Isabel Siegle, Thomas Klein +4 more
The expression of COX-2, but not the expression ofCOX-1, was found to be elevated in a disease-related pattern in the synovial tissue from patients with RA, AS, or PsA in comparison with OA samples, and was especially high in AS synovIAL tissue.
Journal of Pharmacology and Experimental TherapeuticsEffect of COX-1 and COX-2 Inhibition on Induction and Maintenance of Carrageenan-Evoked Thermal Hyperalgesia in Rats
208 Citations1998David M. Dirig, Peter C. Isakson +1 more
This study demonstrates that at least spinal COX-2, if not both COX 1 and COX2, are necessary for the initiation of thermal hyperalgesia, whereas nonspinal sources of prostanoids are important for the maintenance of thermalhyperalgesIA associated with tissue injury and inflammation.
Annals of the Rheumatic DiseasesAn articular index for the assessment of osteoarthritis.
133 Citations1981David Doyle, Paul Dieppe +2 more
In a double-blind, cross-over trial the articular index was sufficiently sensitive to detect a statistically significant difference between the responses of patients with OA to an anti-inflammatory agent and to a simple analgesic.
PubMedControversies in the detection and management of nonsteroidal antiinflammatory drug-induced side effects of the upper gastrointestinal tract.
92 Citations1989Barrier Ch, Hirschowitz Bi
The purpose of this report is to define the clinically important gastrointestinal complications of non steroidal antiinflammatory drug treatment and to examine the need for, and the options in the diagnosis, prevention and treatment of these complications.
NeuroreportCarrageenan-induced hyperalgesia is associated with increased cyclo-oxygenase-2 expression in spinal cord
84 Citations1997Catriona Hay, Jacqueline de Belleroche
Intraplantar injection of carrageenan caused a marked hyperalgesia at 4 h which was significantly attenuated by treatment with DuP 697, which indicates the existence of a potential regulatory mechanism to overcome COX-2 inhibition.
Archives of Internal MedicineNSAID Gastropathy
70 Citations1996Sanford H. Roth
In patients receiving older NSAIDs, the choice of NSAID should be based on differences in formulations at the lowest effective dose, and Gastroprotective cotherapy should be instituted if treatment with olderNSAIDs is continued in at-risk patients.
British Journal of Clinical PharmacologyJoint pain and quality of life; results of a randomised trial.
68 Citations1989G. Parr, B. Darekar +2 more
Health status or quality of life, energy, sleep, social isolation and emotional reactions did not differ significantly between the two treatment groups, but both treatment groups showed improvement during the trial.
PubMedNonsteroidal antiinflammatory drug discontinuation in patients with osteoarthritis.
61 Citations1995D. Scholes, Andy Stergachis +3 more
NSAID discontinuation rates are high among patients with OA and risk of discontinuation differed between NSAID, even after controlling for the effects of such variables as age, disease severity, and concomitant therapy.
PubMedProblems associated with pain measurement in arthritis: comparison of the visual analogue and verbal rating scales.
37 Citations1985Langley Gb, H. Sheppeard
Although the visual analogue scale proved superior to the verbal rating scale in its ability to detect changes in pain, until more is known about factors which influence subjective magnitude estimation, this conclusion must remain tentative.
InflammopharmacologyA clinician’s view of strategies for preventing NSAID-induced gastrointestinal ulcers
11 Citations1996Jia Xin Huang, Richard H. Hunt
The purpose of this article is to review, from a clinician’s point of view, the wide spectrum of GI damage induced by NSAIDs, the possible mechanism of action of NSAIDs and strategies for treating and preventing NSAID-induced GI lesions.
A Clinician’s View of Strategies for Preventing Nsaid-Induced Gastrointestinal Ulcers
9 Citations1997Jia Xin Huang, Richard H. Hunt