SUPPRESSION OF SYMPATHETIC NERVOUS FUNCTION IN LOW-RENIN ESSENTIAL HYPERTENSION
The LancetPublished 1 July 1976Open access
Murray Esler, Otelio S. Randall, John G. Bennett, Andrew J. Zweifler, Stevo Julius, P Rydelek
Citations105
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TL;DR
It is proposed that the syndrome of low-renin essential hypertension is of diverse aetiology, but with secondary sympathetic nervous system underactivity as a feature common to the various forms.
Abstract
Study of general haemodynamics in 15 patients with low-renin essential hypertension showed haemodynamic and pathophysiological heterogeneity. However, there was suppression of sympathetic nervous system function in all low-renin patients, regardless of haemodynamic pattern. Subnormal sympathetic nervous activity was manifested by a low normal mean plasma-noradrenaline concentration at rest, diminished noradrenaline responsiveness to postural stimulation, and a reduced blood-pressure response to the indirectly acting sympathomimetic amine tyramine. It is proposed that the syndrome of low-renin essential hypertension is of diverse aetiology, but with secondary sympathetic nervous system underactivity as a feature common to the various forms. The low plasmarenin activity is probably an expression of defective sympathetic nervous system stimulation of renin release.
Keywords
MedicineEngineering
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