Isolation of T-Cell Tropic HTLV-III-Like Retrovirus from Macaques
SciencePublished 7 June 1985
M. D. Daniel, N L Letvin, N. W. King, Mari Kannagi, Priya Sehgal, R. D. Hunt
Citations906
SJR quartileQ1
SJR score10.42
SNIP6.62
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TL;DR
The isolation of a T-cell tropic retrovirus from three immunodeficient macaques and one macaque with lymphoma is described, and it is indicated that it is related to the causative agent of acquired immune deficiency syndrome in humans.
Abstract
The isolation of a T-cell tropic retrovirus from three immunodeficient macaques and one macaque with lymphoma is described. The morphology, growth characteristics, and antigenic properties of this virus indicate that it is related to the causative agent of acquired immune deficiency syndrome in humans (HTLV-III or LAV). This virus is referred to as simian T-lymphotropic virus type III (STLV-III) of macaques. The existence of a cytopathic, T-cell tropic virus resembling HTLV-III in monkeys may facilitate study of disease induction and vaccine development in an animal model.
Keywords
Immunology and MicrobiologyAgricultural and Biological Sciences
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