Flavonoid intake and risk of chronic diseases
American Journal of Clinical NutritionPublished 1 September 2002
Paul Knekt, Jorma Kumpulainen, Ritva Järvinen, Harri Rissanen, Markku Heliövaara, Antti Reunanen
Citations1,750
SJR quartileQ1
SJR score2.11
SNIP1.75
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
The risk of some chronic diseases may be lower at higher dietary flavonoid intakes, and a trend toward a reduction in risk of type 2 diabetes was associated with higher quercetin intakes.
Abstract
The risk of some chronic diseases may be lower at higher dietary flavonoid intakes.
Keywords
Medicine
Journal of the Royal Statistical Society Series B (Statistical Methodology)Regression Models and Life-Tables
39,259 Citations1972D. R. Cox
Free Radical Biology and MedicineStructure-antioxidant activity relationships of flavonoids and phenolic acids
8,936 Citations1996Catherine Rice‐Evans, Nicholas J. Miller +1 more
The factors underlying the influence of the different classes of polyphenols in enhancing their resistance to oxidation are discussed and support the contention that the partition coefficients of the flavonoids as well as their rates of reaction with the relevant radicals define the antioxidant activities in the lipophilic phase.
New England Journal of MedicineBeyond Cholesterol
6,420 Citations1989Franklin H. Epstein, Daniel Steinberg +4 more
Pharmacological ReviewsThe Effects of Plant Flavonoids on Mammalian Cells:Implications for Inflammation, Heart Disease, and Cancer
4,837 Citations2000Elliott Middleton, Chithan Kandaswami +1 more
Western medicine has not yet used flavonoids therapeutically, even though their safety record is exceptional, and suggestions are made where such possibilities may be worth pursuing.
World review of nutrition and dieteticsThe Flavonoids. A Class of Semi-Essential Food Components: Their Role in Human Nutrition
1,481 Citations2015Joachim K�hnau
Journal of Agricultural and Food ChemistryContent of potentially anticarcinogenic flavonoids of 28 vegetables and 9 fruits commonly consumed in the Netherlands
1,373 Citations1992Michaël G. L. Hertog, P.C.H. Hollman +1 more
The content of the potentially anticarcinogenic flavonoids quercetin, kaempferol, myricet in, apigenin, and luteolin of 28 vegetables and 9 fruits was determined by RP-HPLC with UVdetection.
BMJFlavonoid intake and coronary mortality in Finland: a cohort study
1,269 Citations1996Paul Knekt, Ritva Jarvinen +2 more
Flavonoids offer an explanation for the suggested beneficial effect of fruits and vegetables in coronary heart disease and people with very low intakes of flavonoids have higher risks of coronary disease.
Nutrition and CancerIntake of potentially anticarcinogenic flavonoids and their determinants in adults in the Netherlands
1,217 Citations1993Michaël G. L. Hertog, P.C.H. Hollman +2 more
The use of new analytic technology suggests that in the past flavonoid intake has been overestimated fivefold, but on a milligram-per-day basis, the intake of the antioxidant flavonoids still exceeded that of the antioxidants beta-carotene and vitamin E.
Free Radical Biology and MedicineFree radicals and diabetes
1,104 Citations1988Larry W. Oberley
Not only are oxygen radicals involved in the cause of diabetes, they also appear to play a role in some of the complications seen in long-term treatment of diabetes.
European Journal of CancerRole of oxygen free radicals in cancer development
846 Citations1996D. Dreher, A. Junod
Reducing the avoidable endogenous and exogenous causes of oxidative stress is, for the present, the safest option and new insights in the action of tumour suppressor genes and the DNA repair mechanisms may lead the way to additional tools against carcinogenesis from OFR.
Cancer Causes & ControlVegetables, fruit, and cancer. II. Mechanisms
811 Citations1991Kristi A. Steinmetz, John D. Potter
It was concluded that consumption of higher levels of vegetables and fruit is associated consistently, although not universally, with a reduced risk of cancer at most sites, and particularly with epithelial cancers of the alimentary and respiratory tracts.
Journal of Agricultural and Food ChemistryContent of the Flavonols Quercetin, Myricetin, and Kaempferol in 25 Edible Berries
778 Citations1999Sari Häkkinen, Sirpa Kärenlampi +3 more
The total contents of these flavonols in cranberry, bog whortleberry, lingonberry, black currant, and crowberry were higher than those in the commonly consumed fruits or vegetables, except for onion, kale, and broccoli.
American Journal of EpidemiologyDietary Flavonoids and the Risk of Lung Cancer and Other Malignant Neoplasms
770 Citations1997Paul Knekt, R. J rvinen +5 more
The association between flavonoid intake and lung cancer incidence was not due to the intake of antioxidant vitamins or other potential confounding factors, as adjustment for factors such as smoking and intakes of energy, vitamin E, vitamin C, and beta-carotene did not materially alter the results.
Acta OncologicaData Quality and Quality Control of a Population-Based Cancer Registry: Experience in Finland
646 Citations1994L Teppo, Eero Pukkala +1 more
Active research policy and ambitious, research-oriented staff with competence in medicine, biostatistics and computer science are essential in terms of maintaining good data quality.
Annals of Internal MedicineRelation between Intake of Flavonoids and Risk for Coronary Heart Disease in Male Health Professionals
563 Citations1996Eric B. Rimm, Martijn B. Katan +3 more
The association between intake of flavonols and flavones and coronary heart disease in 34 789 men who were enrolled in the Health Professionals Follow-up Study and were followed prospectively for 6 years was investigated.
MetabolismOxidative stress and glycemic regulation
544 Citations2000Antonio Ceriello
It is hypothesized that a vicious circle between hyperinsulinemia and free radicals could be operating: insulin resistance might cause elevated plasma free radical concentrations, which, in turn, might be responsible for a deterioration of insulin action, with hyperglycemia being a contributory factor.
Archives of Internal MedicineDietary Flavonoids, Antioxidant Vitamins, and Incidence of Stroke
528 Citations1996Sirving O. Keli
The habitual intake of flavonoids and their major source (tea) may protect against stroke.
American Journal of Clinical NutritionAntioxidant flavonols and ischemic heart disease in a Welsh population of men: the Caerphilly Study
514 Citations1997M.G.L. Hertog, P M Sweetnam +3 more
It is concluded that intake of antioxidant flavonols is not inversely associated with IHD risk in the United Kingdom, and experimental evidence suggests that adding milk to tea abolishes the plasma antioxidant-raising capacity of tea.
American Journal of EpidemiologyDietary Flavonoid Intake and Risk of Cardiovascular Disease in Postmenopausal Women
439 Citations1999Laura Yochum, Lawrence H. Kushi +2 more
Of the foods that contributed the most to flavonoids intake in this cohort, only broccoli was strongly associated with reduced risk of CHD death, and the data of this study suggest that flavonoid intake may reduce risk of death from CHD in postmenopausal women.
Advances in experimental medicine and biologyFree Radical Scavenging and Antioxidant Activity of Plant Flavonoids
386 Citations1994Chithan Kandaswami, Elliott Middleton
Their increased production seems to accompany most forms of tissue injury, and the formation of free radicals has been implicated in a multitude of disease states ranging from inflammatory/immune injury to myocardial infarction and cancer.
Journal of Agricultural and Food ChemistryDetermination of Flavonoids in Plant Material by HPLC with Diode-Array and Electro-Array Detections
378 Citations2000Pirjo Mattila, Jouni Astola +1 more
A high-performance liquid chromatographic (HPLC) method with in-line connected diode-array (DAD) and electro- array (EC) detection to identify and quantify 17 flavonoids in plant-derived foods is described.
The LancetAntioxidant flavonols and coronary heart disease risk
372 Citations1997Michaël G. L. Hertog, Edith J. M. Feskens +1 more
Ten years of follow-up of the Zutphen Elderly Study is completed and the recalculated relative-risk estimates are reported, finding that flavonol intake at baseline was inversely associated with CHD mortality.
Nutrition and CancerDietary flavonoids and cancer risk in the Zutphen elderly study
275 Citations1994Michaël G. L. Hertog, Edith J. M. Feskens +3 more
It is concluded that intake of flavonoids, mainly from tea, apples, and onions, does not predict a reduced risk of all-cause cancer or of cancer of the alimentary and respiratory tract in elderly men, and the presence of other nonvitamin components with anticarcinogenic potential in these foods is suggested.
Journal of the American Dietetic AssociationVitamin E content of foods
266 Citations1979Patrick J. McLaughlin, John L. Weihrauch
Tables showing representative values for the vitamin E content of human foods have been developed from all the available reliable information and the biologic activities of these forms are used to calculate approximate vitamin activity values of representative foods.
British Journal Of NutritionAntioxidants and fatty acids in the amelioration of rheumatoid arthritis and related disorders
248 Citations2001L. Gail Darlington, Trevor W. Stone
StrokeIntake of Flavonoids, Carotenoids, Vitamins C and E, and Risk of Stroke in Male Smokers
216 Citations2000Tero Hirvonen, Jarmo Virtamo +3 more
Dietary intake of &bgr;-carotene was inversely associated with the risk for cerebral infarction and no association was detected between other dietary antioxidants and risk for stroke.
Preventive MedicineChanges in Diet in Finland from 1972 to 1992: Impact on Coronary Heart Disease Risk
195 Citations1996Pirjo Pietinen, Erkki Vartiainen +3 more
Dietary changes seem to explain the decrease in serum cholesterol, which has been on average 1.0 mmol/liter (38 mg/dl) in Finland since 1972, together with a decline in smoking among males as well as better blood pressure control they have contributed to the dramatic decline in coronary heart disease mortality in Finland.
European Journal of Clinical NutritionQuercetin intake and the incidence of cerebrovascular disease
174 Citations2000Paul Knekt, S Isotupa +6 more
Results suggest that the intake of apples is related to a decreased risk of thrombotic stroke, and this association apparently is not due to the presence of the antioxidant flavonoid quercetin.
EpidemiologyIntake of Flavonols and Flavones and Risk of Coronary Heart Disease in Male Smokers
170 Citations2001Tero Hirvonen, Pirjo Pietinen +5 more
Proceedings of The Society for Experimental Biology and MedicineTea Flavonols in Cardiovascular Disease and Cancer Epidemiology
161 Citations1999P.C.H. Hollman, Edith J. M. Feskens +1 more
The question of whether flavonol protect against cardiovascular disease remains still open; a protective effect of flavonols against cancer is less likely.
American Journal of Clinical NutritionDietary fat and risk of breast cancer
158 Citations1990Paul Knekt, Demetrius Albanes +6 more
The present data suggest that breast cancer is associated inversely with energy intake and weakly positively with energy-adjusted fat intake.
PubMedThe Social Insurance Institution's coronary heart disease study. Baseline data and 5-year mortality experience.
150 Citations1983Antti Reunanen, Arpo Aromaa +4 more
Acta Medica ScandinavicaValidity of Hospital Discharge Data in a Prospective Epidemiological Study on Stroke and Myocardial Infarction
101 Citations1984Markku Heliövaara, Antti Reunanen +4 more
The validity and coverage of hospital records of stroke and myocardial infarction were evaluated in a Finnish epidemiological cohort and were sufficiently valid for many epidemiological purposes, e.g. research on predictors of diseases.
Journal of the American College of NutritionAsthma and oxidant stress: nutritional, environmental, and genetic risk factors.
92 Citations1995Lawrence S. Greene
Simple dietary and environmental interventions may significantly reduce oxidant stress and prevent or minimize the development of asthmatic symptoms and should prove to be a cost effective approach to asthma management in addition to current pharmacological strategies.
PubMedThe ARA 1987 revised criteria select patients with clinical rheumatoid arthritis from a population based cohort of subjects with chronic rheumatic diseases registered for drug reimbursement.
71 Citations1993Markku Hakala, R Pöllänen +1 more
The 103 patients who met the new ARA criteria had significantly more interventions, such as hospitalization, drug treatment and orthopedic surgery, than the subjects who despite a clinician's primary diagnosis of RA did not fulfill the criteria.
International Journal of EpidemiologyShort-Term and Long-Term Reproducibility of Dietary History Interview Data
63 Citations1993RITVA JÄRVINEN, Ritva Seppänen +1 more
It is suggested that the reproducibility of the dietary history method used was acceptable, and that the dietary patterns of examinees were sufficiently stable to be compatible with the needs of epidemiological follow-up studies.
Flavonols and flavones in foods and their relation with cancer and coronary heart disease risk
42 Citations1994M.G.L. Hertog
It is concluded that intake of flavonols and flavones may protect against coronary heart disease in humans, but that it does not seem to be an important determinant of cancer risk.
Advances in experimental medicine and biologyProtein Oxidation and Proteolytic Degradation General Aspects and Relationship to Cataract Formation
27 Citations1990Kelvin J.A. Davies
A 700,000 dalton neutral endoproteinase, which is called macroxyproteinase or M.O.P., appears to be mostly responsible for the degradation of oxidatively denatured proteins, and appears to also exist in many other mammalian cell types.
Helda (University of Helsinki)Epidemiological follow-up study on dietary antioxidant vitamins. Results from the Finnish Mobile Clinic Health Examination Survey
8 Citations1996Riikka Järvinen