LOW DOSES OF HEPARIN IN PREVENTION OF DEEP-VEIN THROMBOSIS
The LancetPublished 1 September 1971
V V Kakkar, Andrew Nicolaides, E S Field, P.T. Flute, Stanford Wessler, E.T. Yin
Citations252
SJR quartileQ1
SJR score12.11
SNIP22.72
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TL;DR
The effectiveness of subcutaneous heparin in the prophylaxis of deep-vein thrombosis was investigated in 53 consecutive patients over the age of 50 undergoing repair of inguinal hernia.
Abstract
The effectiveness of subcutaneous heparin in the prophylaxis of deep-vein thrombosis was investigated in 53 consecutive patients over the age of 50 undergoing repair of inguinal hernia. Deep-vein thrombosis was detected by means of the 125I-fibrinogen test in 7 (26%) of the 27 control patients, while this was significantly reduced (4%) in the 26 similar patients who received heparin before and after surgery.
Keywords
Medicine
The American Journal of SurgeryDeep vein thrombosis of the leg
477 Citations1970V V Kakkar, C T Howe +3 more
Two hundred and three patients undergoing elective surgery were investigated to determine the group of patients who are at a “great risk” of developing deep vein thrombosis during the postoperative period, and it was found that the patients who formed this group included those who had a history of previous deep vein dilation or pulmonary embolism.
British journal of surgery125I-labelled fibrinogen in the diagnosis of deep-vein thrombosis and its correlation with phlebography
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The Lancet125I-LABELLED FIBRINOGEN TEST ADAPTED FOR ROUTINE SCREENING FOR DEEP-VEIN THROMBOSIS
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It is suggested that the 125 I-labelled fibrinogen test with the ratemeter is a suitable method for the routine screening of at-risk patients.
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It is suggested that the key function of activated Factor X inhibitor as a natural anticoagulant may be primarily concerned with regulating hemostatic balance through neutralization ofactivated Factor X, a reaction profoundly enhanced by traces of heparin.
Journal of Biological ChemistryBiological Properties of the Naturally Occurring Plasma Inhibitor to Activated Factor X
165 Citations1971E.T. Yin, Stanford Wessler +1 more
The efficiency ofactivated Factor X inhibitor as an anticoagulant during normal blood coagulation may depend more on its preventing any generated activated Factor X from activating prothrombin than it may on preventing thrombin from attacking fibrinogen.
The LancetPOSTOPERATIVE DEEP-VEIN THROMBOSIS
150 Citations1969C Flanc, V V Kakkar +1 more
The 125 I-labelled-fibrinogen test permits the incidence and progression of postoperative deep-vein thrombosis to be accurately assessed and is applicable to major operations in the elderly.
The LancetPREVENTION OF FATAL POSTOPERATIVE THROMBOEMBOLISM BY HEPARIN PROPHYLAXIS
130 Citations1970J. G. Sharnoff
In each of the only 2 instances where excessive bleeding at operation was attributed to heparin, this complication was traced to inadvertently incorrect administration of the anticoagulant.
Journal of Biological ChemistryRabbit Plasma Inhibitor of the Activated Species of Blood Coagulation Factor X
84 Citations1971E.T. Yin, Stanford Wessler +1 more
A naturally occurring inhibitor of activated blood coagulation Factor X has been isolated from pooled rabbit plasma and purified by the combination of Sephadex G-200 gel filtration, DEAE-SephadeX A-50, and DEAE -cellulose chromatography.
British journal of surgeryTreatment of deep-vein thrombosis with streptokinase
53 Citations1969V V Kakkar, C Flanc +4 more
Theoretical advantages in using an agent, such as streptokinase, which is known to activate fibrinolysis, which have a potent anticoagulant effect, especially in the critical early stage.