Stimulant and depressant properties of sedative-hypnotics in mice selectively bred for differential sensitivity to ethanol
PsychopharmacologyPublished 1 December 1983
Bruce C. Dudek, Michael E. Abbott, Tamara J. Phillips
Citations57
SJR quartileQ1
SJR score1.16
SNIP0.97
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
A genetic analysis of sedative-hypnotic response in selectively bred Long-Sleep and Short-Sleep mice showed LS mice to be more depressed by acetaldehyde, ethanol, and t-butanol, but less sensitive to pentobarbital.
Abstract
A genetic analysis of sedative-hypnotic response in selectively bred Long-Sleep (LS) and Short-Sleep (SS) mice showed LS mice to be more depressed by acetaldehyde, ethanol (ETOH), and t-butanol, but less sensitive to pentobarbital. Intermediate inheritance was shown by the two reciprocal F1 hybrids for the alcohols, but dominance to the LS genotype occurred for the aldehyde and the barbiturate. At several subhypnotic doses of ETOH in two experiments, LS mice showed less locomotor stimulation and greater disruption of coordination than the SS mice. The two reciprocal F1 hybrids did not differ from one another and had dose-response curves intermediate to the two parental lines. Study of the effects of t-butanol on locomotor activity revealed a pattern of line differences similar to that for ETOH. The genetic selection for LS and SS mice appears to have differentiated loci that pleiotropically influence a variety of behavioral responses to alcohols.
Keywords
Neuroscience
Biobehavioral ReviewsBiphasic action of ethanol
373 Citations1977Larissa A. Pohorecky
Physiological, behavioral, and biochemical evidence demonstrating the excitatory and depressant effects of ethanol in man and experimental animals is reviewed and some implications and possible mechanisms for the biphasic actions of ethanol are discussed.
Life SciencesA comparison of the effects of alcohol on mice selectively bred for differences in ethanol sleep-time
174 Citations1974Warren Heston, V. Gene Erwin +2 more
The results suggest that the two lines of mice selectively bred for differences in “sleep-time” to ethanol differ in their central nervous system sensitivity to ethanol.
Pharmacology Biochemistry and BehaviorEffect of hypnotics on mice genetically selected for sensitivity to ethanol
144 Citations1976V. Gene Erwin, Warren Heston +2 more
The data indicate that while the SS and LS lines of mice differ in central nervous system sensitivity to ethanol, methanol, butanol and t-butanol it is implied that they do no differ inCentral nervous systemensitivity to other hypnotic agents tested.
Pharmacology Biochemistry and BehaviorThe excitatory component of ethanol in mice: A chronic study
116 Citations1980Jandira Masur, Roseli Boerngen
An excitatory effect of ethanol is observed after tolerance develops to its depressant action and tolerance to the excitatories effect was not reached after 60 days of ethanol treatment.
Alcoholism Clinical and Experimental ResearchCharacterization of Acute and Chronic Tolerance in Mice Selected for Inherent Differences in Sensitivity to Ethanol
104 Citations1980Boris Tabakoff, Ronald F. Ritzmann +2 more
No evidence for the development of acute tolerance was evident in mice of either of the selected lines or the offspring of an LS by SS cross (F1), and no metabolic tolerance developed during the 5-day alcohol treatment period.
PsychopharmacologyThe alcohol facilitation effect on memory: A dose-response study
91 Citations1981Elizabeth S. Parker, John M. Morihisa +4 more
It is suggested that a particular phase of the rising blood alcohol curve (0.02–0.03 g/100 ml) facilitates trace consolidation and the facilitating and possibly excitatory effects of alcohol may be important for understanding the rewarding aspects of drinking.
Journal of Comparative and Physiological PsychologySensitivity to low doses of ethanol and pentobarbital in mice selected for sensitivity to hypnotic doses of ethanol.
72 Citations1976Barbara Sanders
SS mice were more active in an open-field test after ethanol than were LS mice, and a similar difference in the open- field activity of the selected lines was observed with pentobarbital.
Pharmacology Biochemistry and BehaviorEthanol-induced depressions in cerebellar and hippocampal neurons of mice selectively bred for differences in ethanol sensitivity: An electrophysiological study
68 Citations1981S.M. Sorensen, Thomas V. Dunwiddie +3 more
Data strongly suggest that whatever genetically determined central nervous alterations result in the differential soporific effects of ethanol in the two (LS and SS) mouse lines, such alterations are brain region- and depressant drug-specific rather than generalized.
Life SciencesEthanol-induced hypothermia in mice: Influence of genotype on development of tolerance
61 Citations1978Jerome A. Moore, Ryoko Kakihana
Repeated injection of ethanol results in the decrease of hypothermia in BALB/c mice and in C57BL, but not in DBA/2 mice, indicating that tolerance as measured in this study may not develop in certain genotypes of mice.
Life SciencesDifferential effects of pentobarbital and ethanol in mice
53 Citations1976Albert J. Siemens, Arthur W.K. Chan
Factors which govern the brain sensitivities of selected mouse strains to ethanol and pentobarbital may not be equivalent.
JAMAPsychopharmacological Elements of Drug Dependence
51 Citations1968M.H. SEEVERS
This paper argues that if all the population were to be given a drug trial with every major psychoactive drug by intravenous administration and then permitted free access to the drug of their choice, a large majority of the world population will inevitably become drug dependent.
PsychopharmacologyEffects of gamma-butyrolactone, amphetamine, and haloperidol in mice differing in sensitivity to alcohol
49 Citations1980Bruce C. Dudek, Richard J. Fanelli
Gamma-butyrolactone induced longer loss of righting reflex in mice (LS-line) selectively bred for greater sensitivity to ethanol than in less sensitive SS-line mice, and induced a three-fold greater increase of brain dopamine levels in LS than in SS mice.
Alcoholism Clinical and Experimental ResearchCircadian and Genetic Effects on Ethanol Elimination in LS and SS Mice
41 Citations1982David M. Gilliam, Allan C. Collins
Overall mean BAC for LS mice was significantly higher than for SS mice at both ethanol doses, and SS mice showed a significantly greater overall rate of decline than did LS mice, which may contribute to circadian influences on ethanol response.
Drug and Alcohol DependenceGenetics and ethanol tolerance
40 Citations1979Gerald E. McClearn, Sally M. Anderson
This paper reviews some of the research on genetic bases of individual differences in ethanol tolerance of mice conducted at the Institute for Behavioral Genetics and at its predecessor laboratory at the University of California, Berkeley to illustrate the general approaches available for addressing the issue.
Pharmacology Biochemistry and BehaviorEffects of pentobarbital in mice selected for differential sensitivity to ethanol
38 Citations1982Michael O’Connor, Thomas C. Howerton +1 more
Dose-dependent differences in sleep time and in hypothermia were found, with SS mice affected to a greater degree than LS mice, and an altered rate of elimination appeared to be the major factor responsible for the differences observed between these lines.
PsychopharmacologyActivating and anesthetic effects of general depressants
37 Citations1978Barbara Sanders, Seth K. Sharpless +3 more
The long-sleep (LS) and short-sleep) lines of mice were derived by selective breeding with respect to ethanol sleep time and it was found that in current generations LS mice also have longer sleep times than SS mice to trichloroethanol and paraldehyde.
Journal of Studies on AlcoholThree heritable responses to alcohol in a heterogeneous randomly mated mouse strain. Inferences for humans.
32 Citations1977T. Edward Reed
Alcohol-induced heart-rate change, open-field activity changes and sleeping time were found to be significantly heritable in mice and may have parallels in man and mouse in their alcohol responses and genetics.
Behavior GeneticsAlbinism and auditory function in the laboratory mouse. I. Effects of single-gene substitutions on auditory physiology, audiogenic seizures, and developmental processes
31 Citations1975Kenneth R. Henry, Mark M. Haythorn
It was concluded that thec genes worked in an additive fashion to delay development during the period previously found critical for inducing susceptibility to audiogenic seizures.
Drug and Alcohol DependenceBehavioral effects of salsolinol and ethanol on mice selected for sensitivity to alcohol-induced sleep time
24 Citations1977Allen C. Church, J. L. Fuller +1 more
Two lines of mice, selected for differential sensitivity to alcohol, were tested following intracisternal administration of salsolinol, a compound putatively formed following ethanol ingestion, and found that LS mice were more incapacitated than SS mice.
Behavior Research MethodsThe grid test: A measure of alcohol- and barbiturate-induced behavioral impairment in mice
24 Citations1975John K. Belknap
PsychopharmacologyEvidence for parallel development of tolerance to the hyperactivating and discoordinating effects of ethanol
20 Citations1977Geoffrey Hunt, David H. Overstreet
The present studies have shown a parallel development of tolerance to the discoordinating and hyperactivating effects of ethanol and have implicated an underlying noradrenergic and/or dopaminergic mechanism, although the precise nature of the mechanism has not been clarified.
Pharmacology Biochemistry and BehaviorEthanol consumption and hepatic enzyme activity
18 Citations1979Sally M. Anderson, Gerald E. McClearn +1 more
The total liver alcohol dehydrogenase activity was found to be 24% higher in the HEA line than in the LEA line after five generations of selective breeding, and no association between cytosolic aldehyde dehydrogenases activity and ethanol acceptance was found in either the F2 generation or the fifth generation of the selectively bred lines.