Specific Effects of Neurotransmitter Antagonists on Ganglion Cells in Rabbit Retina
SciencePublished 16 January 1976
Harry J. Wyatt, Nigel W. Day
Citations160
SJR quartileQ1
SJR score10.42
SNIP6.62
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TL;DR
Directionally sensitive ganglion cells in rabbit retina lose their directional sensitivity when picrotoxin, an antagonist of the inhibitory neurotransmitter gamma-aminobutyric acid, is infused into the retinal blood supply.
Abstract
Directionally sensitive ganglion cells in rabbit retina lose their directional sensitivity when picrotoxin, an antagonist of the inhibitory neurotransmitter gamma-aminobutyric acid, is infused into the retinal blood supply. Strychnine, an antagonist of glycine, does not produce this effect. Other receptive field types are affected by strychnine but not picrotoxin. Inhibitory transmitters therefore have specific functions in information processing in the retina.
Keywords
NeuroscienceBiochemistry, Genetics and Molecular Biology
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It is concluded, that neither acetylcholine nor noradrenaline are the main and only transmitters of retinal excitation or inhibition.
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