Accuracy of Rapid and Point-of-Care Screening Tests for Hepatitis C
Annals of Internal MedicinePublished 16 October 2012
Sushmita Shivkumar, Rosanna Ŵ. Peeling, Yalda Jafari, Lawrence Joseph, Nitika Pant Pai
Citations145
SJR quartileQ1
SJR score3.38
SNIP3.27
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
Data suggest that POCTs of blood (serum, plasma, or whole blood) have the highest accuracy, followed by RDTs of serum or plasma and POCTS of oral fluids, which may be useful in expanding first-line screening for hepatitis C.
Abstract
Canadian Institutes of Health Research.
Keywords
Medicine
Annals of Internal MedicineQUADAS-2: A Revised Tool for the Quality Assessment of Diagnostic Accuracy Studies
13,994 Citations2011Penny Whiting, Anne W.S. Rutjes +8 more
The QUADAS-2 tool will allow for more transparent rating of bias and applicability of primary diagnostic accuracy studies and is applied in 4 phases.
The Lancet Infectious DiseasesGlobal epidemiology of hepatitis C virus infection
2,741 Citations2005Colin W. Shepard, Lyn Finelli +1 more
Because there is no vaccine and no post-exposure prophylaxis for HCV, the focus of primary prevention efforts should be safer blood supply in the developing world, safe injection practices in health care and other settings, and decreasing the number of people who initiate injection drug use.
Journal of Clinical EpidemiologyThe diagnostic odds ratio: a single indicator of test performance
2,294 Citations2003Afina S. Glas, Jeroen G. Lijmer +3 more
JAMAUsers' Guides to the Medical Literature
2,178 Citations1994Roman Jaeschke
The patient is a 28-year-old man whose acute onset of shortness of breath and vague chest pain began shortly after completing a 10-hour auto trip, and the physician is very apprehensive about his symptoms.
BMJStatistics Notes: Diagnostic tests 1: sensitivity and specificity
1,996 Citations1994Douglas G. Altman, J Martin Bland
The simplest diagnostic test is one where the results of an investigation, such as an x ray examination or biopsy, are used to classify patients into two groups according to the presence or absence of a symptom or sign.
JAMAUsers' guides to the medical literature. III. How to use an article about a diagnostic test. B. What are the results and will they help me in caring for my patients? The Evidence-Based Medicine Working Group
1,830 Citations1994Roman Jaeschke
You are back where you were in the previous article1 on diagnostic tests: in the library studying an article that will guide you in interpreting ventilation-perfusion (V/Q) lung scans.
American PharmacySexually Transmitted Diseases 7982 Treatment Guidelines
1,581 Citations1982Kimberly Workowski, Stuart M. Berman
BMJDiagnostic tests 4: likelihood ratios
1,579 Citations2004Jonathan J Deeks, Douglas G. Altman
Likelihood ratios are alternative statistics for summarising diagnostic accuracy, which have several particularly powerful properties that make them more useful clinically than other statistics.
Journal of HepatologyEpidemiology of viral hepatitis and HIV co-infection
1,006 Citations2005Miriam J. Alter
The characteristics of HIV infected persons differ according to the co-infecting hepatitis virus, their epidemiologic patterns may change over time, and surveillance systems are needed to monitor their infection patterns in order to ensure that prevention measures are targeted appropriately.
International Journal of Medical SciencesThe Natural History of Hepatitis C Virus (HCV) Infection
848 Citations2006Stephen L. Chen, Timothy R. Morgan
An understanding of the natural history of hepatitis C is essential to effectively manage, treat, and counsel individuals with HCV infection.
Annals of Internal MedicineSources of Variation and Bias in Studies of Diagnostic Accuracy
777 Citations2004Penny Whiting, Anne WS Rutjes +4 more
A systematic review of all studies in which the main focus was examine the effects of one or more sources of bias or variation on estimates of test performance, to classify the various sources of variation and bias, describe their effects on test results, and provide a summary of the available evidence that supports each source of bias and variation.
Data Archiving and Networked Services (DANS)Towards complete and accurate reporting of studies of diagnostic accuracy: The STARD Initiative
697 Citations2003
PubMedGuidelines for laboratory testing and result reporting of antibody to hepatitis C virus. Centers for Disease Control and Prevention.
322 Citations2003Miriam J. Alter, Wendi L. Kuhnert +1 more
These guidelines expand recommendations for anti-HCV testing to include an option for reflex supplemental testing based on screening-test-positive signal-to-cut-off (s/co) ratios, which minimizes the amount of supplemental testing that needs to be performed while improving the reliability of reported test results.
Clinical Infectious DiseasesInfluence of Coinfection with Hepatitis C Virus on Morbidity and Mortality Due to Human Immunodeficiency Virus Infection in the Era of Highly Active Antiretroviral Therapy
175 Citations2003Ellen Tedaldi, Rose Baker +7 more
Age, baseline CD4+ cell count, and duration of HAART were significantly associated with survival, but HCV infection was not, suggesting that treatment is more important to survival than is HCV coinfection status.
Journal of InfectionPrevalence of infection with hepatitis B and C virus and coinfection with HIV in medical inpatients in Malawi
124 Citations2008Mulinda Nyirenda, M.B.J. Beadsworth +6 more
The high prevalence of hepatitis/HIV coinfections may impact on treatment with antiretroviral therapy, especially if there are unintended interruptions of therapy, and studies are needed to document the possible clinical impact on ART programmes.
Journal of Virological MethodsEvaluation of a new, rapid test for detecting HCV infection, suitable for use with blood or oral fluid
112 Citations2010Stephen R. Lee, Keith Kardos +18 more
D detection of anti-HCV in oral fluid appeared generally robust to conditions of oral health, consumption of food and drink and use of oral care products, and may increase testing opportunities due to its simplicity and flexibility to use multiple specimen types, including fingerstick blood and oral fluid.
The Journal of Infectious DiseasesEvaluation of Three Rapid Screening Assays for Detection of Antibodies to Hepatitis C Virus
92 Citations2011Bryce D. Smith, Jan Drobeniuc +6 more
Rapid anti- HCV tests can provide sensitive and specific anti-HCV results for high-risk patients and are associated with human immunodeficiency virus positivity for both approaches for Chembio and MedMira.
American Journal of Public HealthPublic Health Implications of Rapid Hepatitis C Screening With an Oral Swab for Community-Based Organizations Serving High-Risk Populations
79 Citations2011Ann Drobnik, Caroline Judd +4 more
OraQuick's accuracy is comparable to the EIA and could help HCV screening programs reach individuals unaware of their status and expand testing into nonclinical settings such as mobile units.
Journal of Clinical VirologyEvaluation of a rapid, point-of-care test device for the diagnosis of hepatitis C infection
77 Citations2010S.R. Lee, Graham Yearwood +6 more
Sensitivity and specificity of the rapid HCV Rapid Antibody Test was equivalent to laboratory EIA and performance was comparable across all 5 specimen types.
Clinical Infectious DiseasesPerformance of Premarket Rapid Hepatitis C Virus Antibody Assays in 4 National Human Immunodeficiency Virus Behavioral Surveillance System Sites
75 Citations2011Bryce D. Smith, Eyasu H. Teshale +16 more
Sitive rapid anti-HCV assays are appropriate and feasible for high-prevalence, high-risk populations such as PWID, who can be reached through social service settings such as syringe exchange programs and methadone maintenance treatment programs.
AIDS CareDrug users talk about HIV testing: Motivating and deterring factors
54 Citations2001Moher Downing, Kelly R. Knight +6 more
The complexity and range of motivations and deterrents to HIV testing among IDUs can help providers develop a more holistic approach to targeting this high-risk population for HIV prevention efforts.
PubMedEvaluation of rapid kits for detection of HIV, HBsAg and HCV infections.
46 Citations2000Harjeet Kaur, J Dhanao +1 more
Diagnostic kits (J. Mitra Co. Ltd) for rapid detection of HIV, HBsAg & HCV were evaluated against respective enzyme immunoassay (Ortho Diagnostics) and all rapid kits were 100% specific for HIV.
Indian Journal of Medical MicrobiologyComparison of ELISA and rapid screening tests for the diagnosis of HIV, hepatitis B and hepatitis C among healthy blood donors in a tertiary care hospital in Mumbai
45 Citations2008VP Torane, JS Shastri
1. Probing the catalytic activity of a cell division-speciÞ c transpeptidase in vivo with beta lactams finds no evidence of inhibition of cell division in patients treated with antibiotics.
Journal of Virological MethodsDetection of HCV antibodies in oral fluid
41 Citations2004L. De Cock, Veronik Hutse +4 more
It is suggested that the modified ELISA method for anti-HCV detection in oral fluid can be used for epidemiological surveys.
Sexually Transmitted InfectionsRapid and simple point of care diagnostics for STIs
39 Citations2001David Mabey
The high prevalence of asymptomatic gonococcal and chlamydial infections is one of the greatest obstacles to STI control, especially in developing countries, where partner notification is difficult.
Journal of Clinical MicrobiologyEvaluation of a Rapid Assay as an Alternative to Conventional Enzyme Immunoassays for Detection of Hepatitis C Virus-Specific Antibodies
24 Citations2005Hubert Darius J. Daniel, Priya Abraham +4 more
A rapid membrane flow-through immunoassay to detect antibodies to hepatitis C virus was compared with a commercial enzyme immunoASSay (EIA) and microparticle enzyme immunOassay (MEIA) using 2,590 serum samples and found this assay is suitable where infrastructure and laboratory expertise are limited.
PubMedRapid and simple hepatitis assays: encouraging results from a blood donor population in Zimbabwe.
22 Citations1996D Mvere, Niel T. Constantine +4 more
All the rapid/simple tests were easy to perform and interpret, required no (or minimal) laboratory equipment, and could be taught easily to local laboratory personnel.
Clinica Chimica ActaA rapid test for the visual detection of anti-hepatitis C virus antibodies in whole blood
18 Citations1999Lucio Montebugnoli, Giorgio Borea +2 more
The HCV Ab rapid test showed a very high accuracy and could be very useful for the detection of HCV-positive subjects in situations where rapid results are required or technical expertise is limited.
HepatologyHepatitis C Drug Development at a Crossroads†
18 Citations2009David R. Nelson
Perhaps the most relevant conclusion of the PROVE and SPRINT trials is that PEG-IFN and RBV will remain critical elements in new treatment regimens, and standard-dose RBV is required to optimize response to these first-generation protease inhibitors.
Journal of Virological MethodsA cost-effective algorithm for the diagnosis of Hepatitis C virus infection and prediction of HCV viremia in Cameroon
15 Citations2005Richard Njouom, Mathurin Cyrille Tejiokem +5 more
The results suggest an algorithm using ImmunoComb II HCV as a first test to screen anti-HCV positive subjects, and Hexagon HCVs as a second test to discriminate between viremic and non-viremic HCV seropositive subjects.
The American Journal of GastroenterologyThe accuracy of SM-HCV rapid test for the detection of antibody to hepatitis C virus
14 Citations2001Man‐Fung Yuen
The American Journal of GastroenterologyThe accuracy of SM-HCV rapid test for the detection of antibody to hepatitis C virus
13 Citations2001MF Yuen, Hui Chen +3 more
SM-HCV Rapid Test is a reliable test with high sensitivity and specificity for the detection of antibody to hepatitis C virus with reference to the well-established third generation enzyme immunoblot assay EIA-3.
The Brazilian Journal of Infectious DiseasesHigh prevalence of hepatitis C associated with familial history of hepatitis in a small town of south Brazil. Efficiency of the rapid test for epidemiological survey
11 Citations2010Cláudia Alexandra Pontes Ivantes, Danilo R. Silva +1 more
The familial history of hepatitis was a significant risk factor to the infection and HCV rapid test showed to be accurate and feasible for epidemiological survey and a high prevalence of anti-HCV in Tamboara was demonstrated.
PubMedComparative results in detection of HCV antibodies by using a rapid HCV test, ELISA and immunoblot.
11 Citations1994Yong Poovorawan, Apiradee Theamboonlers +2 more
Comparison results in detection of HCV antibodies by using GLD HCV-SPOT, ELISA and GLD/DBL HCV BLOT are reported.
The Brazilian Journal of Infectious DiseasesHigh prevalence of hepatitis C associated with familial history of hepatitis in a small town of south Brazil: efficiency of the rapid test for epidemiological survey
10 Citations2010Cláudia Alexandra Pontes Ivantes, Danilo R. Silva +1 more
The familial history of hepatitis was a significant risk factor to the infection and HCV rapid test showed to be accurate and feasible for epidemiological survey and a high prevalence of anti-HCV in Tamboara was demonstrated.