Multiple steroid receptors in male breast carcinomas

Specific cytosol receptors for estradiol, progesterone and dihydrotestosterone were detected in human male breast carcinomas and the properties and binding specificity were very similar to those found in female breast tumors.

Abstract

We present a statistical mechanical model based on the principle of mass action that explains the main features of the in vitro aggregation behavior of the coat protein of tobacco mosaic virus (TMV). By comparing our model to experimentally obtained stability diagrams, titration experiments, and calorimetric data, we pin down three competing factors that regulate the transitions between the different kinds of aggregated state of the coat protein. These are hydrophobic interactions, electrostatic interactions, and the formation of so-called "Caspar" carboxylate pairs. We suggest that these factors could be universal and relevant to a large class of virus coat proteins.